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本文引用的文献

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Liver biopsy findings for HIV-infected patients with chronic hepatitis C and persistently normal levels of alanine aminotransferase.丙型肝炎慢性感染且丙氨酸转氨酶水平持续正常的HIV感染患者的肝活检结果
Clin Infect Dis. 2006 Sep 1;43(5):640-4. doi: 10.1086/506440. Epub 2006 Jul 27.
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Liver fibrosis in HIV-positive patients with hepatitis C virus: role of persistently normal alanine aminotransferase levels.丙型肝炎病毒感染的HIV阳性患者的肝纤维化：丙氨酸氨基转移酶水平持续正常的作用
J Acquir Immune Defic Syndr. 2006 Jan 1;41(1):63-7. doi: 10.1097/01.qai.0000192001.15777.15.
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Coinfection with HIV and hepatitis C virus among injection drug users in southern China.中国南方注射吸毒者中艾滋病毒与丙型肝炎病毒的合并感染情况。
Clin Infect Dis. 2005 Jul 1;41 Suppl 1:S18-24. doi: 10.1086/429491.
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Advances in chronic viral hepatitis.慢性病毒性肝炎的进展
Curr Opin Infect Dis. 2005 Oct;18(5):400-6. doi: 10.1097/01.qco.0000180163.84271.5e.
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Prediction of hepatic fibrosis in HIV/HCV co-infected patients using serum fibrosis markers: the SHASTA index.使用血清纤维化标志物预测HIV/HCV合并感染患者的肝纤维化：SHASTA指数
J Hepatol. 2005 Jul;43(1):78-84. doi: 10.1016/j.jhep.2005.02.025. Epub 2005 Apr 25.
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Cirrhosis and hepatocellular carcinoma in HIV-infected veterans with and without the hepatitis C virus: a cohort study, 1992-2001.1992 - 2001年对感染和未感染丙型肝炎病毒的HIV感染退伍军人的肝硬化和肝细胞癌进行的队列研究
Arch Intern Med. 2004 Nov 22;164(21):2349-54. doi: 10.1001/archinte.164.21.2349.
7
Human immunodeficiency and hepatitis virus infections and their associated conditions and treatments among people with haemophilia.血友病患者中的人类免疫缺陷病毒和肝炎病毒感染及其相关病症与治疗
Haemophilia. 2004 Oct;10 Suppl 4:205-10. doi: 10.1111/j.1365-2516.2004.00997.x.
8
Mortality due to hepatitis C-related liver disease in HIV-infected patients in France (Mortavic 2001 study).法国HIV感染患者中丙型肝炎相关肝病导致的死亡率（Mortavic 2001研究）
AIDS. 2003 Aug 15;17(12):1803-9. doi: 10.1097/00002030-200308150-00009.
9
High prevalence of HIV-1 and hepatitis C virus coinfection among injection drug users in the southeastern region of Yunnan, China.中国云南省东南部地区注射吸毒者中艾滋病毒-1与丙型肝炎病毒合并感染的高流行率。
J Acquir Immune Defic Syndr. 2002 Feb 1;29(2):191-6. doi: 10.1097/00042560-200202010-00014.
10
Increasing impact of chronic viral hepatitis on hospital admissions and mortality among HIV-infected patients.慢性病毒性肝炎对HIV感染患者住院率和死亡率的影响日益增加。
AIDS Res Hum Retroviruses. 2001 Nov 1;17(16):1467-71. doi: 10.1089/08892220152644160.

血液分析在合并感染人类免疫缺陷病毒和肝炎病毒的血友病患者中的意义。

Significance of blood analysis in hemophiliacs co-infected with human immunodeficiency virus and hepatitis viruses.

作者信息

Shen Fang, Huang Qin, Sun Hong-Qing, Ghildyal Reena

机构信息

Shanghai Medical College and Shanghai Public Health Center, Fudan University, Shanghai 201508, China.

出版信息

World J Gastroenterol. 2007 Mar 28;13(12):1862-6. doi: 10.3748/wjg.v13.i12.1862.

DOI:10.3748/wjg.v13.i12.1862
PMID:17465482
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4149968/
Abstract

AIM

To study the effect of hepatitis virus infection on cirrhosis and liver function markers in HIV-infected hemophiliacs.

METHODS

We have analyzed the immunological, liver function and cirrhosis markers in a cohort of hemophiliacs co-infected with human immunodeficiency virus (HIV) and hepatitis viruses.

RESULTS

There was no difference in immunological markers among co-infected patients and patients infected with HIV only and those co-infected with one or more hepatitis virus. Although liver function and cirrhosis markers remained within a normal range, there was a worsening trend in all patients co-infected with hepatitis virus C (HCV), which was further exacerbated in the presence of additional infection with hepatitis virus B (HBV).

CONCLUSION

Co-infection with HIV, HBV and HCV leads to worsening of hyaluronic acid and liver function markers. Increases in serum hyaluronic acid may be suggestive of a predisposition to liver diseases.

摘要

目的

研究肝炎病毒感染对感染人类免疫缺陷病毒（HIV）的血友病患者肝硬化及肝功能指标的影响。

方法

我们分析了一组同时感染人类免疫缺陷病毒（HIV）和肝炎病毒的血友病患者的免疫指标、肝功能及肝硬化指标。

结果

合并感染患者、仅感染HIV的患者以及合并感染一种或多种肝炎病毒的患者之间免疫指标无差异。虽然肝功能和肝硬化指标仍在正常范围内，但所有丙型肝炎病毒（HCV）合并感染患者均有恶化趋势，在合并乙型肝炎病毒（HBV）感染时这种趋势进一步加剧。

结论

HIV、HBV和HCV合并感染导致透明质酸和肝功能指标恶化。血清透明质酸升高可能提示易患肝脏疾病。