血液分析在合并感染人类免疫缺陷病毒和肝炎病毒的血友病患者中的意义。
Significance of blood analysis in hemophiliacs co-infected with human immunodeficiency virus and hepatitis viruses.
作者信息
Shen Fang, Huang Qin, Sun Hong-Qing, Ghildyal Reena
机构信息
Shanghai Medical College and Shanghai Public Health Center, Fudan University, Shanghai 201508, China.
出版信息
World J Gastroenterol. 2007 Mar 28;13(12):1862-6. doi: 10.3748/wjg.v13.i12.1862.
AIM
To study the effect of hepatitis virus infection on cirrhosis and liver function markers in HIV-infected hemophiliacs.
METHODS
We have analyzed the immunological, liver function and cirrhosis markers in a cohort of hemophiliacs co-infected with human immunodeficiency virus (HIV) and hepatitis viruses.
RESULTS
There was no difference in immunological markers among co-infected patients and patients infected with HIV only and those co-infected with one or more hepatitis virus. Although liver function and cirrhosis markers remained within a normal range, there was a worsening trend in all patients co-infected with hepatitis virus C (HCV), which was further exacerbated in the presence of additional infection with hepatitis virus B (HBV).
CONCLUSION
Co-infection with HIV, HBV and HCV leads to worsening of hyaluronic acid and liver function markers. Increases in serum hyaluronic acid may be suggestive of a predisposition to liver diseases.
目的
研究肝炎病毒感染对感染人类免疫缺陷病毒（HIV）的血友病患者肝硬化及肝功能指标的影响。
方法
我们分析了一组同时感染人类免疫缺陷病毒（HIV）和肝炎病毒的血友病患者的免疫指标、肝功能及肝硬化指标。
结果
合并感染患者、仅感染HIV的患者以及合并感染一种或多种肝炎病毒的患者之间免疫指标无差异。虽然肝功能和肝硬化指标仍在正常范围内，但所有丙型肝炎病毒（HCV）合并感染患者均有恶化趋势，在合并乙型肝炎病毒（HBV）感染时这种趋势进一步加剧。
结论
HIV、HBV和HCV合并感染导致透明质酸和肝功能指标恶化。血清透明质酸升高可能提示易患肝脏疾病。
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