Huang Xiaohua, El-Sayed Ivan H, Qian Wei, El-Sayed Mostafa A
Laser Dynamics Laboratory, School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, Georgia 30332, USA.
Nano Lett. 2007 Jun;7(6):1591-7. doi: 10.1021/nl070472c. Epub 2007 May 3.
Human oral cancer cells are found to assemble and align gold nanorods conjugated to anti-epidermal growth factor receptor (anti-EGFR) antibodies. Immnoconjugated gold nanorods and nanospheres were shown previously to exhibit strong Rayleigh (Mie) scattering useful for imaging. In the present letter, molecules near the nanorods on the cancer cells are found to give a Raman spectrum that is greatly enhanced (due to the high surface plasmon field of the nanorod assembly in which their extended surface plasmon fields overlap), sharp (due to a homogeneous environment), and polarized (due to anisotropic alignments). These observed properties can be used as diagnostic signatures for cancer cells.
研究发现，人类口腔癌细胞会组装并排列与抗表皮生长因子受体（anti-EGFR）抗体偶联的金纳米棒。免疫偶联的金纳米棒和纳米球此前已被证明具有用于成像的强瑞利（米氏）散射。在本信函中，发现癌细胞上纳米棒附近的分子给出的拉曼光谱有极大增强（这是由于纳米棒组装体的高表面等离子体场，其中它们的扩展表面等离子体场相互重叠）、尖锐（由于环境均匀）且具有偏振性（由于各向异性排列）。这些观察到的特性可作为癌细胞的诊断特征。
