Schäfer Matthias, Werner Sabine
Institute of Cell Biology, Department of Biology, ETH Zurich, Zurich, Switzerland.
Annu Rev Cell Dev Biol. 2007;23:69-92. doi: 10.1146/annurev.cellbio.23.090506.123609.
Injury to the skin initiates a complex process of events involving inflammation as well as the formation and remodeling of new tissue. These processes result in at least partial reconstitution of the injured skin. However, wounds in adult mammals heal with a scar, which is accompanied by functional and aesthetic impairments. In addition to this problem, a large number of patients, in particular in the aged population, suffer from chronic, nonhealing ulcers. Therefore, there is a strong need to improve the wound healing process. This requires a thorough understanding of the underlying molecular and cellular mechanisms. During the past several years, important regulators of the wound healing process have been identified. In particular, the growth factors and matrix proteins, which orchestrate skin repair, have been characterized in detail. By contrast, much less is known about the transcription factors, which regulate gene expression at the wound site. This review summarizes recent data on the expression of transcription factors in skin wounds and their functions in the repair process.
皮肤损伤会引发一系列复杂的事件过程，涉及炎症以及新组织的形成和重塑。这些过程至少会使受损皮肤得到部分修复。然而，成年哺乳动物的伤口愈合会留下疤痕，同时伴有功能和美观方面的损伤。除了这个问题，大量患者，尤其是老年人群，患有慢性不愈合溃疡。因此，迫切需要改善伤口愈合过程。这需要深入了解其潜在的分子和细胞机制。在过去几年中，已经确定了伤口愈合过程的重要调节因子。特别是，精心协调皮肤修复的生长因子和基质蛋白已得到详细表征。相比之下，对于在伤口部位调节基因表达的转录因子，我们了解得要少得多。这篇综述总结了关于皮肤伤口中转录因子表达及其在修复过程中功能的最新数据。
