Haertel Eric, Werner Sabine, Schäfer Matthias
Institute of Molecular Health Sciences, Department of Biology, Swiss Federal Institute of Technology (ETH) Zurich, CH 8093 Zurich, Switzerland.
Institute of Molecular Health Sciences, Department of Biology, Swiss Federal Institute of Technology (ETH) Zurich, CH 8093 Zurich, Switzerland.
Semin Immunol. 2014 Aug;26(4):321-8. doi: 10.1016/j.smim.2014.01.005. Epub 2014 Feb 17.
The attraction and activation of immune cells is an important response of the skin to injury and allows an efficient defense against invading pathogens. In addition, immune cells fulfill various functions that are important for the repair process. An exaggerated inflammatory response, however, is a hallmark of chronic, non-healing wounds. Therefore, it is essential to strictly control and coordinate the levels and activities of various immune cells in normal and wounded skin. Recent studies provided insight into the molecular mechanisms underlying the inflammatory response after wounding, and various transcriptional regulators involved in this process have been identified. This review summarizes our current knowledge on the function of different transcription factors in wound repair, with particular emphasis on proteins with a documented role in the control of wound inflammation.
免疫细胞的吸引和激活是皮肤对损伤的重要反应，能有效抵御入侵病原体。此外，免疫细胞还履行着对修复过程至关重要的各种功能。然而，过度的炎症反应是慢性难愈合伤口的一个标志。因此，严格控制和协调正常皮肤和受伤皮肤中各种免疫细胞的水平和活性至关重要。最近的研究深入了解了伤口后炎症反应的分子机制，并确定了参与这一过程的各种转录调节因子。本综述总结了我们目前对不同转录因子在伤口修复中功能的认识，特别强调了在控制伤口炎症中具有明确作用的蛋白质。
