利用免疫系统治疗癌症。
Harnessing the immune system to treat cancer.
作者信息
Bhardwaj Nina
机构信息
Departments of Pathology, Medicine, and Dermatology, New York University School of Medicine, NYU Medical Center, 550 First Avenue, New York, NY 10016, USA.
出版信息
J Clin Invest. 2007 May;117(5):1130-6. doi: 10.1172/JCI32136.
Abstract
A major challenge for the immune system is to recognize and eliminate cells undergoing carcinogenesis. Immune defense against tumors is complex. It can be mediated early by the innate immune system (i.e., phagocytes, NK cells, NKT cells, cytokines, and complement proteins) and later by the adaptive immune system (i.e., B cells and T cells). The eight articles in this Review series on tumor immunology discuss the mechanisms underlying immune surveillance of tumors, the regulation of carcinogenesis by immune inflammatory mediators, current approaches to controlling tumor growth through immunotherapy, and novel targets of immunotherapy.
摘要
免疫系统面临的一个主要挑战是识别并清除正在发生癌变的细胞。针对肿瘤的免疫防御是复杂的。它早期可由先天免疫系统介导（即吞噬细胞、自然杀伤细胞、自然杀伤T细胞、细胞因子和补体蛋白），后期则由适应性免疫系统介导（即B细胞和T细胞）。本肿瘤免疫学综述系列中的八篇文章讨论了肿瘤免疫监视的潜在机制、免疫炎症介质对癌变的调节、目前通过免疫疗法控制肿瘤生长的方法以及免疫疗法的新靶点。
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Harnessing the immune system to treat cancer.利用免疫系统治疗癌症。
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Cancer vaccine development: on the way to break immune tolerance to malignant cells.癌症疫苗研发：迈向打破对恶性细胞免疫耐受的征程。
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Role of the circular RNAs/microRNA/messenger RNA axis in renal cell carcinoma: From gene regulation to metabolism and immunity.环状RNA/微小RNA/信使RNA轴在肾细胞癌中的作用：从基因调控到代谢与免疫
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Correlation of LOXL2 expression in non-small cell lung cancer with immunotherapy.非小细胞肺癌中LOXL2表达与免疫治疗的相关性
Int J Clin Exp Pathol. 2024 Sep 15;17(9):268-286. doi: 10.62347/ZIEG9007. eCollection 2024.
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Potential predictors of immunotherapy in small cell lung cancer.小细胞肺癌免疫治疗的潜在预测因子。
Pathol Oncol Res. 2023 May 3;29:1611086. doi: 10.3389/pore.2023.1611086. eCollection 2023.
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Circular RNA cancer vaccines drive immunity in hard-to-treat malignancies.环状 RNA 癌症疫苗可激发难以治疗的恶性肿瘤的免疫反应。
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Synthesis, Characterization, and Cytokinome Profile of IL-12-Loaded PLGA Nanospheres.载白细胞介素-12 的 PLGA 纳米球的合成、表征及细胞因子谱分析。
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Subtyping of microsatellite stability colorectal cancer reveals guanylate binding protein 2 (GBP2) as a potential immunotherapeutic target.微卫星稳定型结直肠癌的亚型分析显示鸟苷酸结合蛋白 2（GBP2）是一个潜在的免疫治疗靶点。
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Extracellular vesicle-mediated communication between hepatocytes and natural killer cells promotes hepatocellular tumorigenesis.细胞外囊泡介导的肝细胞与自然杀伤细胞之间的通讯促进了肝细胞肿瘤的发生。
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Effects of checkpoint kinase 1 inhibition by prexasertib on the tumor immune microenvironment of head and neck squamous cell carcinoma.普雷沙替尼对头颈部鳞状细胞癌肿瘤免疫微环境的影响。
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本文引用的文献
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Principles of adoptive T cell cancer therapy.过继性T细胞癌症治疗的原则。
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DC-based cancer vaccines.基于树突状细胞的癌症疫苗。
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Development of TLR9 agonists for cancer therapy.用于癌症治疗的Toll样受体9激动剂的研发。
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A cytokine-mediated link between innate immunity, inflammation, and cancer.先天性免疫、炎症和癌症之间由细胞因子介导的联系。
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Tregs and rethinking cancer immunotherapy.调节性T细胞与癌症免疫治疗的再思考
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6
Altered macrophage differentiation and immune dysfunction in tumor development.肿瘤发生过程中巨噬细胞分化改变与免疫功能障碍
J Clin Invest. 2007 May;117(5):1155-66. doi: 10.1172/JCI31422.
7
Indoleamine 2,3-dioxygenase and tumor-induced tolerance.吲哚胺2,3-双加氧酶与肿瘤诱导的免疫耐受。
J Clin Invest. 2007 May;117(5):1147-54. doi: 10.1172/JCI31178.
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Immune surveillance of tumors.肿瘤的免疫监视
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Thymic development and peripheral homeostasis of regulatory T cells.调节性T细胞的胸腺发育与外周稳态
Curr Opin Immunol. 2007 Apr;19(2):176-85. doi: 10.1016/j.coi.2007.02.005. Epub 2007 Feb 15.
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Hematopoietic stem cells promote the expansion and function of adoptively transferred antitumor CD8 T cells.造血干细胞促进过继转移的抗肿瘤CD8 T细胞的扩增和功能。
J Clin Invest. 2007 Feb;117(2):492-501. doi: 10.1172/JCI30414.
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