Bhardwaj Nina
Departments of Pathology, Medicine, and Dermatology, New York University School of Medicine, NYU Medical Center, 550 First Avenue, New York, NY 10016, USA.
J Clin Invest. 2007 May;117(5):1130-6. doi: 10.1172/JCI32136.
A major challenge for the immune system is to recognize and eliminate cells undergoing carcinogenesis. Immune defense against tumors is complex. It can be mediated early by the innate immune system (i.e., phagocytes, NK cells, NKT cells, cytokines, and complement proteins) and later by the adaptive immune system (i.e., B cells and T cells). The eight articles in this Review series on tumor immunology discuss the mechanisms underlying immune surveillance of tumors, the regulation of carcinogenesis by immune inflammatory mediators, current approaches to controlling tumor growth through immunotherapy, and novel targets of immunotherapy.
免疫系统面临的一个主要挑战是识别并清除正在发生癌变的细胞。针对肿瘤的免疫防御是复杂的。它早期可由先天免疫系统介导（即吞噬细胞、自然杀伤细胞、自然杀伤T细胞、细胞因子和补体蛋白），后期则由适应性免疫系统介导（即B细胞和T细胞）。本肿瘤免疫学综述系列中的八篇文章讨论了肿瘤免疫监视的潜在机制、免疫炎症介质对癌变的调节、目前通过免疫疗法控制肿瘤生长的方法以及免疫疗法的新靶点。
