Valentini G, Improta R D, Resse M, Migliaresi S, Minucci P B, Tirri R, Farzati B, Tirri G
Department of Medicine, 1st Faculty of Medicine, University of Naples 'Federico II', Italy.
Br J Rheumatol. 1991 Dec;30(6):429-32. doi: 10.1093/rheumatology/30.6.429.
Antinuclear antibodies (ANA), as detected by indirect immunofluorescence on HEp-2 cells, have been investigated in five spouses and 41 first-degree relatives of nine probands with polymyositis-dermatomyositis (PM-DM) and in 41 sex- and age-matched controls. ANA were detected in 12 out of the 41 first-degree relatives and in two controls (chi 2 = 6.97; P less than 0.01). HLA typing was done in four out of the nine families; in two of them only, ANA segregated with a haplotype. ANA positivity was not correlated either to sex or to age or to household contact. Our results show that ANA occur in a significant percentage of first-degree relatives of patients with PM-DM. The finding seems to be genetically conditioned.
通过对人喉表皮癌细胞（HEp - 2细胞）进行间接免疫荧光检测抗核抗体（ANA），研究了9例多发性肌炎 - 皮肌炎（PM - DM）先证者的5名配偶和41名一级亲属，以及41名年龄和性别匹配的对照者。41名一级亲属中有12人检测到ANA，41名对照者中有2人检测到ANA（χ² = 6.97；P < 0.01）。对9个家族中的4个进行了人类白细胞抗原（HLA）分型；其中只有2个家族中，ANA与一个单倍型分离。ANA阳性与性别、年龄或家庭接触均无相关性。我们的结果表明，PM - DM患者的一级亲属中有相当比例存在ANA。这一发现似乎受遗传因素影响。
