Walker G L, Mastaglia F L, Roberts D F
Acta Neurol Scand. 1982 Oct;66(4):432-43. doi: 10.1111/j.1600-0404.1982.tb06865.x.
33 patients with idiopathic inflammatory myopathies (polymyositis or dermatomyositis) and 45 of their first-degree relatives were investigated in a search for any influence of genetic factors in these diseases. None of the relatives had evidence of an inflammatory myopathy but 13 had some other autoimmune disease. Mean serum IgG levels were reduced and serum C3c concentration increased both in patients and relatives. Levels of IgM were reduced and C4 increased in some groups of patients. The incidence of autoantibodies was increased in the patient group, particularly in those with isolated dermatomyositis or other systemic features, but not in the relatives. HLA, blood group and other genetic markers showed no deviation from normal population frequencies. Evidence favouring a genetic influence on the etiology of idiopathic inflammatory myopathy is restricted to disturbance of levels of some Ig and complement components, and for these there may be other explanations.
对33例特发性炎性肌病（多发性肌炎或皮肌炎）患者及其45名一级亲属进行了调查，以探寻遗传因素对这些疾病的影响。亲属中均无炎性肌病的证据，但有13人患有其他自身免疫性疾病。患者及其亲属的平均血清IgG水平降低，血清C3c浓度升高。部分患者组IgM水平降低，C4升高。患者组自身抗体的发生率增加，尤其是孤立性皮肌炎或有其他全身特征的患者，但亲属中未增加。人类白细胞抗原（HLA）、血型及其他遗传标记与正常人群频率无偏差。支持遗传因素对特发性炎性肌病病因有影响的证据仅限于某些免疫球蛋白（Ig）和补体成分水平的紊乱，而对此可能还有其他解释。
