Pezo Rossanna C, Singer Robert H
Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York, USA.
J Cell Biochem. 2008 Aug 15;104(6):1953-63. doi: 10.1002/jcb.21353.
The nuclear architecture plays an important role in the temporal and spatial control of complex functional processes within the nucleus. Alterations in nuclear structures are characteristic of cancer cells and the mechanisms underlying these perturbations may directly contribute to tumor development and progression. In this review, we will highlight aspects of the nuclear microenvironment that are perturbed during tumorigenesis and discuss how a greater understanding of the role of nuclear structure in the control of gene expression can provide new options for cancer diagnosis and treatment.
核结构在细胞核内复杂功能过程的时空控制中起着重要作用。核结构的改变是癌细胞的特征，这些扰动背后的机制可能直接促进肿瘤的发生和发展。在本综述中，我们将重点介绍肿瘤发生过程中受到扰动的核微环境的各个方面，并讨论对核结构在基因表达控制中的作用有更深入的了解如何能为癌症诊断和治疗提供新的选择。
