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2
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3
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本文引用的文献

1
Stability of the patient acceptable symptomatic state over time in outcome criteria in ankylosing spondylitis.强直性脊柱炎结局标准中患者可接受症状状态随时间的稳定性。
Arthritis Rheum. 2006 Dec 15;55(6):960-3. doi: 10.1002/art.22342.
2
Feeling good rather than feeling better matters more to patients.对患者来说，感觉良好而非感觉好转更为重要。
Arthritis Rheum. 2006 Aug 15;55(4):526-30. doi: 10.1002/art.22110.
3
The cost of dichotomising continuous variables.将连续变量二分的代价。
BMJ. 2006 May 6;332(7549):1080. doi: 10.1136/bmj.332.7549.1080.
4
Minimal disease activity for rheumatoid arthritis: a preliminary definition.类风湿关节炎的最小疾病活动度：一个初步定义。
J Rheumatol. 2005 Oct;32(10):2016-24.
5
Measuring treatment impact: a review of patient-reported outcomes and other efficacy endpoints in approved product labels.衡量治疗效果：对已批准产品标签中患者报告的结局及其他疗效终点的综述。
Control Clin Trials. 2004 Dec;25(6):535-52. doi: 10.1016/j.cct.2004.09.003.
6
Evaluation of clinically relevant changes in patient reported outcomes in knee and hip osteoarthritis: the minimal clinically important improvement.膝关节和髋关节骨关节炎患者报告结局的临床相关变化评估：最小临床重要改善
Ann Rheum Dis. 2005 Jan;64(1):29-33. doi: 10.1136/ard.2004.022905. Epub 2004 Jun 18.
7
Evaluation of clinically relevant states in patient reported outcomes in knee and hip osteoarthritis: the patient acceptable symptom state.膝关节和髋关节骨关节炎患者报告结局中临床相关状态的评估：患者可接受症状状态
Ann Rheum Dis. 2005 Jan;64(1):34-7. doi: 10.1136/ard.2004.023028. Epub 2004 May 6.
8
Patient reported outcomes as endpoints in medical research.患者报告的结局作为医学研究的终点。
Stat Methods Med Res. 2004 Apr;13(2):115-38. doi: 10.1191/0962280204sm357ra.
9
Defining clinically meaningful change in health-related quality of life.定义健康相关生活质量中具有临床意义的变化。
J Clin Epidemiol. 2003 May;56(5):395-407. doi: 10.1016/s0895-4356(03)00044-1.
10
MCID/Low Disease Activity State Workshop: low disease activity state in rheumatoid arthritis.最小临床重要差异/低疾病活动状态研讨会：类风湿关节炎的低疾病活动状态
J Rheumatol. 2003 May;30(5):1110-1.

风湿性疾病主观结局测量的最小临床重要改善及患者可接受症状状态

Minimal clinically important improvement and patient acceptable symptom state for subjective outcome measures in rheumatic disorders.

作者信息

Tubach Florence, Ravaud Philippe, Beaton Dorcas, Boers Maarten, Bombardier Claire, Felson David T, van der Heijde Desireé, Wells George, Dougados Maxime

机构信息

Département d'Epidémiologie, Biostatistique et Recherche Clinique, Hôpital Bichat, Paris, France.

出版信息

J Rheumatol. 2007 May;34(5):1188-93.

PMID:17477485
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2760122/
Abstract

The concepts of minimal clinically important improvement (MCII) and patient acceptable symptomatic state (PASS) could help in interpreting results of trials involving patient-reported outcomes by translating the response at the group level (change in mean scores) into more clinically meaningful information by addressing the patient level as "therapeutic success (yes/no)." The aims of the special interest group (SIG) at OMERACT 8 were to discuss specific issues concerning the MCII and PASS concepts, especially the wording of the external anchor questions used to determine the MCII and PASS estimates, and to move toward a consensus for the cutoff values to use as the MCII and PASS in the different outcome criteria. The purpose of this SIG at OMERACT 8 was to inform participants of the MCII and PASS concepts and to agree on MCII and PASS values for pain, patient global assessment, and functional impairment.

摘要

最小临床重要改善（MCII）和患者可接受症状状态（PASS）的概念有助于解释涉及患者报告结局的试验结果，通过将组水平的反应（平均得分变化）转化为更具临床意义的信息，即将患者水平视为“治疗成功（是/否）”。在骨关节炎研究学会（OMERACT）第8届会议上，特别兴趣小组（SIG）的目标是讨论与MCII和PASS概念相关的具体问题，尤其是用于确定MCII和PASS估计值的外部锚定问题的措辞，并就不同结局标准中用作MCII和PASS的临界值达成共识。OMERACT第8届会议上这个SIG的目的是让参与者了解MCII和PASS概念，并就疼痛、患者整体评估和功能损害的MCII和PASS值达成一致。