Silverman N A, Alexander J C, Hollinshead A C, Chretien P B
Cancer. 1976 Jan;37(1):135-40. doi: 10.1002/1097-0142(197601)37:1<135::aid-cncr2820370120>3.0.co;2-q.
In 94 patients with squamous carcinoma of the head and neck region, the clinical extent of tumor was correlated with in vitro lymphocyte reactivity (LR) to phytohemagglutinin (PHA) and serum complement-fixing antibodies to herpes simplex virus (HSV)-induced tumor-associated antigen (TAA). Forty-six patients were tumor-bearing and 48 were considered cured. Controls were 41 age-matched normals with histories of similar cigarette consumption. In 15 patients with Stage I carcinomas of the larynx, among whom the tumor diameter was 5 mm or less, mean LR or PHA did not differ from controls and 7 of 11 tested (63%) had antibodies to HSV-TAA. In 83 patients with more extensive tumors, LR to PHA was significantly lower than controls and 42 of 44 tested (95%) had antibodies to HSV-TAA. In both groups, LR to PHA was similar among tumor-bearing and cured patients. The study delineates a clinical tumor burden associated with impaired LR to PHA and a high incidence of antibodies to HSV-TAA in patients with squamous carcinomas of the head and neck region, and shows a correlation between the immune defects in clinically cured patients and tumor extent prior to treatment.
在94例头颈部鳞状细胞癌患者中，肿瘤的临床范围与体外淋巴细胞对植物血凝素（PHA）的反应性（LR）以及血清中针对单纯疱疹病毒（HSV）诱导的肿瘤相关抗原（TAA）的补体结合抗体相关。46例患者有肿瘤，48例被认为已治愈。对照组为41名年龄匹配的正常人，吸烟史相似。在15例喉I期癌患者中，肿瘤直径为5毫米或更小，其平均LR或PHA与对照组无差异，11例接受检测的患者中有7例（63%）有针对HSV-TAA的抗体。在83例肿瘤范围更广的患者中，对PHA的LR显著低于对照组，44例接受检测的患者中有42例（95%）有针对HSV-TAA的抗体。在两组中，有肿瘤患者和已治愈患者对PHA的LR相似。该研究描绘了头颈部鳞状细胞癌患者中与对PHA的LR受损相关的临床肿瘤负担以及对HSV-TAA抗体的高发生率，并显示了临床治愈患者的免疫缺陷与治疗前肿瘤范围之间的相关性。
