Smith H G, Chretien P B, Henson D E, Silverman N A, Alexander J C
Am J Surg. 1976 Oct;132(4):541-8. doi: 10.1016/0002-9610(76)90336-6.
Serum antibodies to herpes simplex virus-induced antigens (HSVIA) were quantitated in 122 patients with head and neck squamous carcinoma, 93 patients tumor-free after treatment for these malignant lesions, 27 patients with nonsquamous malignant lesions, 30 heavy smokers, and 36 nonsmokers. Serum IgA anti-HSVIA antibodies were detected in a greater percentage of sera of patients with squamous carcinoma (61 per cent), patients previously treated for these malignant lesions (56 per cent), and heavy smokers (57 per cent) than in patients with nonsquamous malignant lesions (11 per cent) or nonsmokers (8 per cent). Furthermore, titers of these antibodies were higher in patients with squamous carcinoma than in smokers. In patients tumor-free more than three years after treatment, the percentage of positive sera was significantly lower than that in untreated patients and in patients three years or less after treatment. This study demonstrates for the first time a high frequency of antibodies to HSV-induced antigens confined to subjects at high risk of developing head and neck squamous carcinoma and in patients with these malignancies as well as a correlation between the levels of these antibodies and clinical course after treatment.
对122例头颈部鳞状细胞癌患者、93例经治疗后无肿瘤的这些恶性病变患者、27例非鳞状恶性病变患者、30例重度吸烟者和36例非吸烟者，测定了针对单纯疱疹病毒诱导抗原（HSVIA）的血清抗体。在鳞状细胞癌患者（61%）、先前接受过这些恶性病变治疗的患者（56%）和重度吸烟者（57%）的血清中，检测到血清IgA抗HSVIA抗体的比例高于非鳞状恶性病变患者（11%）或非吸烟者（8%）。此外，这些抗体的滴度在鳞状细胞癌患者中高于吸烟者。在治疗后三年以上无肿瘤的患者中，阳性血清的比例显著低于未治疗患者和治疗后三年或更短时间的患者。本研究首次证明，针对HSV诱导抗原的抗体在有发生头颈部鳞状细胞癌高风险的受试者以及这些恶性肿瘤患者中出现的频率很高，并且这些抗体水平与治疗后的临床病程之间存在相关性。
