Shillitoe E J, Tarro G, Lehner T
Oncology. 1976;33(4):192-5. doi: 10.1159/000225141.
Cell-mediated immune responses to herpes simplex virus 1 and type 2 virion and non-virion antigens were assessed in patients and in controls with oral leukoplakia, carcinoma and recurrent herpes labialis. Enhanced proliferation was found in lymphocytes from patients with recurrent herpes labialis or with leukoplakia showing epithelial atypia, and depressed responses were found in carcinoma. Very significantly positive correlations were shown between the responses to each of the herpes virus antigens. A specific increase in cell-mediated immunity to herpes virus in epithelial atypia was confirmed, but separation of the nonvirion from virion antigen is necessary before specific cell-mediated immune responses to the non-virion antigen can be assessed.
在患有口腔白斑、癌症以及复发性唇疱疹的患者和对照者中，评估了针对单纯疱疹病毒1型和2型病毒体及非病毒体抗原的细胞介导免疫反应。发现复发性唇疱疹患者或有上皮异型性的白斑患者的淋巴细胞增殖增强，而癌症患者的反应则受到抑制。对每种疱疹病毒抗原的反应之间显示出非常显著的正相关。上皮异型性中对疱疹病毒的细胞介导免疫有特异性增强得到证实，但在评估对非病毒体抗原的特异性细胞介导免疫反应之前，有必要将非病毒体与病毒体抗原分离。
