Klöppel Günter
Department of Pathology, University of Kiel, Kiel, Schleswig-Holstein, Germany.
Mod Pathol. 2007 Feb;20 Suppl 1:S113-31. doi: 10.1038/modpathol.3800690.
Chronic pancreatitis is a fibroinflammatory disease of the pancreas. Etiologically, most cases are related to alcohol abuse and smoking. Recently, gene mutations have been identified as the cause of hereditary pancreatitis. Other chronic pancreatitis types that were defined in recent years are autoimmune pancreatitis (lymphoplasmacytic sclerosing pancreatitis) and paraduodenal pancreatitis ('groove pancreatitis', 'cystic dystrophy of heterotopic pancreas'). This review describes and discusses the main histological findings, the pathogenesis and the clinical features of the various types of chronic pancreatitis. In addition, pseudotumors and other tumor-like lesions are briefly mentioned.
慢性胰腺炎是胰腺的一种纤维炎性疾病。从病因学角度来看，大多数病例与酗酒和吸烟有关。最近，基因突变已被确定为遗传性胰腺炎的病因。近年来定义的其他慢性胰腺炎类型包括自身免疫性胰腺炎（淋巴浆细胞性硬化性胰腺炎）和十二指肠旁胰腺炎（“沟部胰腺炎”、“异位胰腺的囊性营养不良”）。本综述描述并讨论了各种类型慢性胰腺炎的主要组织学发现、发病机制和临床特征。此外，还简要提及了假肿瘤和其他肿瘤样病变。
