Li Jian, Li Qingwang, Feng Tao, Zhang Tao, Li Kun, Zhao Rui, Han Zengsheng, Gao Dawei
College of Environmental and Chemical Engineering, Yanshan University, Qinhuangdao, Hebei Province 066004, People's Republic of China.
Phytother Res. 2007 Sep;21(9):832-40. doi: 10.1002/ptr.2163.
Solanum nigrum Linne (SNL) has been used in traditional Chinese medicine for centuries because of its diuretic and antipyretic effects. The present study examined the effect of the crude polysaccharides isolated from Solanum nigrum Linne (SNL-P) on tumor growth. SNL-P had a significant growth inhibition effect on cervical cancer (U14) of tumor-bearing mice. Further analysis of the tumor inhibition mechanism indicated that the number of apoptotic tumor cells increased significantly, the expression of Bax increased and the expression of Bcl-2 and mutant p53 decreased dramatically in cervical cancer sections after oral administration of SNL-P for 12 days. Moreover, SNL-P treatment decreased the level of blood serum TNF-alpha. These results indicated that the tumor growth inhibition of SNL-P administration might correlate with the reduction of TNF-alpha level of blood serum, which resulted in a massive necrosis in tumor tissues and the up-regulation of Bax and down-regulation of Bcl-2 and mutant p53 gene expression, which triggered apoptosis in tumor cells. These findings demonstrated that the SNL-P is a potential antitumor agent.
龙葵（Solanum nigrum Linne，SNL）因其利尿和解热作用，在传统中药中已使用了数百年。本研究考察了从龙葵中分离得到的粗多糖（SNL-P）对肿瘤生长的影响。SNL-P对荷瘤小鼠的宫颈癌（U14）具有显著的生长抑制作用。对肿瘤抑制机制的进一步分析表明，口服SNL-P 12天后，宫颈癌切片中凋亡肿瘤细胞数量显著增加，Bax表达上调，Bcl-2和突变型p53表达显著下降。此外，SNL-P治疗降低了血清TNF-α水平。这些结果表明，给予SNL-P抑制肿瘤生长可能与血清TNF-α水平降低有关，这导致肿瘤组织大量坏死，以及Bax上调和Bcl-2及突变型p53基因表达下调，并引发肿瘤细胞凋亡。这些发现表明，SNL-P是一种潜在的抗肿瘤药物。
