水龙的黄酮类化合物及其生物活性。

Flavonoids and biological activities of Jussiaea repens.

作者信息

Marzouk M S, Soliman F M, Shehata I A, Rabee M, Fawzy G A

机构信息

Chemistry of Tannins and Leather Technology Department, National Research Centre, El-Dokki, Cairo, Egypt.

出版信息

Nat Prod Res. 2007 May;21(5):436-43. doi: 10.1080/14786410600943288.

DOI:10.1080/14786410600943288

PMID:17487615

Abstract

A new acylated avicularin, namely avicularin 2''-(4'''-O-n-pentanoyl)-gallate (1) along with 12 metabolites have been isolated from the ethyl acetate extract of the aerial parts of Jussiaea repens L. (Onagraceae). Their structures were established as trifolin 2''-O-gallate (2), quercetrin (3), guaijaverin (4), reynoutrin (5), juglanin (6), avicularin (7), hyperin (8), trifolin (9), hyperin 2''-O-gallate (10), rutin (11), kaempferol (12) and quercetin (13) on the basis of their chromatographic properties, chemical and spectroscopic evidences. The investigated ethyl acetate extract was found to be non-toxic (LD(50) up to the maximum soluble dose 4 g kg(-1) body wt.) and had significant antioxidant, hepatoprotective, anti-inflammatory and antidiabetic activities. Also some of the isolated flavonoids showed cytotoxic activity against Ehrlich ascitis carcinoma cells.

摘要

从水龙（柳叶菜科）地上部分的乙酸乙酯提取物中分离出一种新的酰化扁蓄苷，即扁蓄苷2''-(4'''-O-正戊酰基)-没食子酸酯(1)以及12种代谢产物。根据它们的色谱性质、化学和光谱证据，确定它们的结构分别为三叶豆苷2''-O-没食子酸酯(2)、槲皮苷(3)、桂樱苷(4)、异槲皮苷(5)、胡桃苷(6)、扁蓄苷(7)、金丝桃苷(8)、三叶豆苷(9)、金丝桃苷2''-O-没食子酸酯(10)、芦丁(11)、山柰酚(12)和槲皮素(13)。研究发现，所研究的乙酸乙酯提取物无毒（半数致死量高达最大可溶剂量4 g kg⁻¹体重），并具有显著的抗氧化、保肝、抗炎和抗糖尿病活性。此外，一些分离出的黄酮类化合物对艾氏腹水癌细胞具有细胞毒性活性。