Armstrong David, Mönnikes Hubert, Bardhan Karna Dev, Stanghellini Vincenzo
McMaster University, Hamilton, Ont., Canada.
Digestion. 2007;75 Suppl 1:17-24. doi: 10.1159/000101078. Epub 2007 May 4.
Gastroesophageal reflux disease (GERD) is one of the most prevalent diseases worldwide, and it is becoming increasingly important to monitor the effect of various interventions on GERD symptoms. There can be rapid temporal changes in the severity and frequency of patients' symptoms as well as their health status and well-being, all of which could, theoretically, be monitored using diaries or questionnaires. However, current GERD monitoring instruments are not appropriate because they do not assess symptoms daily, they are not sufficiently responsive to short-term changes in health status or they are not adequately validated. To address these problems, the conceptual and psychometric requirements for a GERD symptom assessment questionnaire were identified. A dimension-based scale was designed to reduce the number of symptoms monitored on a daily basis, and the validation process was defined to produce parallel long and short forms of a scale for patients' self-assessment of their GERD symptom response to therapy. These basic principles which underlie the successful development of a new, self-assessed symptomatic reflux questionnaire (ReQuest) are also applicable to the development of validated questionnaires for daily symptom self-assessment in other disease areas.
胃食管反流病（GERD）是全球最常见的疾病之一，监测各种干预措施对GERD症状的影响变得越来越重要。患者症状的严重程度和频率以及他们的健康状况和幸福感可能会随时间快速变化，从理论上讲，所有这些都可以通过日记或问卷进行监测。然而，目前的GERD监测工具并不合适，因为它们不是每天评估症状，对健康状况的短期变化反应不够灵敏，或者没有经过充分验证。为了解决这些问题，确定了GERD症状评估问卷的概念和心理测量要求。设计了一种基于维度的量表，以减少每日监测的症状数量，并定义了验证过程，以生成用于患者自我评估GERD症状对治疗反应的平行长表和短表。这些构成新的自我评估症状性反流问卷（ReQuest）成功开发基础的基本原则，也适用于其他疾病领域每日症状自我评估的有效问卷的开发。
