Arakawa K, Papazoglou T, Papaioannou T, Shi W Q, Fishbein M, Litvack F, Forrester J S, Grundfest W S
Department of Medicine (Cardiology), Cedars-Sinai Medical Center, Los Angeles, California.
Jpn Circ J. 1991 Nov;55(11):1094-105. doi: 10.1253/jcj.55.1094.
In order to develop a reliable laser-induced fluorescence (LIF) guided laser angioplasty system, real time, pulse-by-pulse fluorescence spectra were recorded and the same fiberoptic was used for both detection of the fluorescence and for atheromatous tissue ablation. A 308 nm XeCl excimer laser served as the laser source for both the induction of fluorescence and the ablation. The fluorescence signal was induced at high laser energies during ablation without any serious change in the fluorescence pattern. A new characteristic fluorescence peak at 540 nm for atheromatous tissue was observed after treatment with chlortetracycline hydrochloride (CTC). This allowed the development of an algorithm and a subsequent index to discriminate the atheromatous tissue from the normal tissue. During atheromatous tissue ablation, this index changed as normal tissue was approached, thereby avoiding vessel perforation. Our results suggest that monitoring of this index through the catheter delivering the laser energy enhances selective ablation while simultaneously reducing the risk of vessel perforation.
为了开发一种可靠的激光诱导荧光（LIF）引导的激光血管成形术系统，记录了实时逐脉冲荧光光谱，并且同一根光纤用于荧光检测和动脉粥样硬化组织消融。一台308 nm XeCl准分子激光器用作诱导荧光和消融的激光源。在消融过程中，在高激光能量下诱导出荧光信号，荧光模式没有任何严重变化。在用盐酸金霉素（CTC）处理后，观察到动脉粥样硬化组织在540 nm处有一个新的特征荧光峰。这使得能够开发一种算法和随后的指标，以区分动脉粥样硬化组织和正常组织。在动脉粥样硬化组织消融过程中，当接近正常组织时，该指标会发生变化，从而避免血管穿孔。我们的结果表明，通过输送激光能量的导管监测该指标可增强选择性消融，同时降低血管穿孔的风险。
