通过天然发射和竹红菌素（HA）探测对心血管动脉粥样硬化沉积物进行激光诱导荧光检测。

Laser-induced fluorescence detection of cardiovascular atherosclerotic deposits via their natural emission and hypocrellin (HA) probing.

作者信息

Papazoglou T G, Liu W Q, Katsamouris A, Fotakis C

机构信息

Foundation for Research and Technology Hellas, Institute of Electronic Structure and Laser, Laser and Applications Division, Heraklion, Crete, Greece.

出版信息

J Photochem Photobiol B. 1994 Feb;22(2):139-44. doi: 10.1016/1011-1344(93)06960-b.

DOI:10.1016/1011-1344(93)06960-b

PMID:8176547

Abstract

In order to develop a reliable laser-induced-fluorescence-guided angioplasty system, fluorescence spectra were recorded during exposure of normal and atherosclerotic cadaveric aortic tissue to He-Cd laser radiation (442 nm). A characteristic increase in the fluorescence signal at 600 nm for atheromatous tissue was observed after treatment of the samples with hypocrellin (HA). This, combined with the spectral distribution of tissue natural fluorescence, allowed the development of simple algorithms, based on the intensity difference and the full width at half-maximum (FWHM), and a subsequent index of discrimination between normal and various atheromatous tissues. Our results suggest that monitoring of this index through the catheter could enhance selective ablation, reducing the risk of normal vessel perforation.

摘要

为了开发一种可靠的激光诱导荧光引导血管成形术系统，在正常和动脉粥样硬化尸体主动脉组织暴露于氦镉激光辐射（442nm）期间记录了荧光光谱。在用竹红菌素（HA）处理样品后，观察到动脉粥样硬化组织在600nm处的荧光信号有特征性增加。这与组织自然荧光的光谱分布相结合，使得能够基于强度差异和半高宽（FWHM）开发简单算法，并随后得出正常组织和各种动脉粥样硬化组织之间的鉴别指数。我们的结果表明，通过导管监测该指数可以增强选择性消融，降低正常血管穿孔的风险。