通过四羧酸根离子染料（BTC）探测和激光诱导荧光光谱法检测心血管钙化沉积物。

Detection of cardiovascular calcified deposits via tetracarboxylate ion dye (BTC) probing and laser-induced fluorescence spectroscopy.

作者信息

Papazoglou T G, Iatridou H, Foukaraki E, Katerinopoulos H E

机构信息

Foundation for Research and Technology Hellas, Institute of Electronic Structure and Laser, Heraklion, Crete, Greece.

出版信息

J Photochem Photobiol B. 1995 Jan;27(1):81-4. doi: 10.1016/1011-1344(94)07052-p.

DOI:10.1016/1011-1344(94)07052-p

PMID:7699525

Abstract

In order to develop a reliable, laser-induced, fluorescence-guided, angioplasty system, fluorescence spectra were recorded during exposure of normal and atherosclerotic cadaveric aortic tissue to argon ion laser irradiation. A characteristic increase in the fluorescence signal in the 520-560 nm spectral region for atheromatous tissue was observed after treatment of the samples with a tetracarboxylate ion dye (BTC). This allowed the development of a simple algorithm (based on the intensity difference) and a subsequent index of discrimination between normal and atheromatous tissue. Our results suggest that monitoring of this index through the catheter could enhance selective ablation.

摘要

为了开发一种可靠的、激光诱导的、荧光引导的血管成形术系统，在正常和动脉粥样硬化尸体主动脉组织暴露于氩离子激光照射期间记录了荧光光谱。在用四羧酸盐离子染料（BTC）处理样品后，观察到动脉粥样硬化组织在520-560nm光谱区域的荧光信号有特征性增加。这使得能够开发一种简单的算法（基于强度差异）以及随后区分正常组织和动脉粥样硬化组织的指标。我们的结果表明，通过导管监测该指标可增强选择性消融。