Bridges Robert L, Wiley Chris R, Christian John C, Strohm Adam P
Alaska Open Imaging Center, Anchorage, Alaska 99504, USA.
J Nucl Med Technol. 2007 Jun;35(2):64-76; quiz 78-9. doi: 10.2967/jnmt.106.032870. Epub 2007 May 11.
Na(18)F, an early bone scintigraphy agent, is poised to reenter mainstream clinical imaging with the present generations of stand-alone PET and PET/CT hybrid scanners. (18)F PET scans promise improved imaging quality for both benign and malignant bone disease, with significantly improved sensitivity and specificity over conventional planar and SPECT bone scans. In this article, basic acquisition information will be presented along with examples of studies related to oncology, sports medicine, and general orthopedics. The use of image fusion of PET bone scans with CT and MRI will be demonstrated. The objectives of this article are to provide the reader with an understanding of the history of early bone scintigraphy in relation to Na(18)F scanning, a familiarity with basic imaging techniques for PET bone scanning, an appreciation of the extent of disease processes that can be imaged with PET bone scanning, an appreciation for the added value of multimodality image fusion with bone disease, and a recognition of the potential role PET bone scanning may play in clinical imaging.
早期骨闪烁显像剂氟化钠（Na(18)F），随着新一代独立式正电子发射断层扫描（PET）和PET/CT混合扫描仪的出现，有望重新进入主流临床成像领域。(18)F PET扫描有望提高对良性和恶性骨疾病的成像质量，与传统的平面和单光子发射计算机断层扫描（SPECT）骨扫描相比，其灵敏度和特异性显著提高。在本文中，将介绍基本采集信息以及与肿瘤学、运动医学和普通骨科相关的研究示例。还将展示PET骨扫描与CT和MRI图像融合的应用。本文的目的是让读者了解与Na(18)F扫描相关的早期骨闪烁显像的历史，熟悉PET骨扫描的基本成像技术，认识到PET骨扫描能够成像的疾病过程范围，了解骨疾病多模态图像融合的附加价值，以及认识到PET骨扫描在临床成像中可能发挥的潜在作用。
