Levin Michael
Center for Regenerative and Developmental Biology, Forsyth Institute and Developmental Biology Department, Harvard School of Dental Medicine, Boston, MA 02115, USA.
Trends Cell Biol. 2007 Jun;17(6):261-70. doi: 10.1016/j.tcb.2007.04.007. Epub 2007 May 10.
Regeneration requires exquisite orchestration of growth and morphogenesis. A powerful but still largely mysterious system of biophysical signals functions during regeneration, embryonic development and neoplasm. Ion transporters generate pH and voltage gradients, as well as ion fluxes, regulating proliferation, differentiation and migration. Endogenous bioelectrical signals are implicated in the control of wound healing, limb development, left-right patterning and spinal cord regeneration. Recent advances in molecular biology and imaging technology have allowed unprecedented insight into the sources and downstream consequences of ion flows. In complement to the current focus on molecular genetics and stem cell biology, artificial modulation of bioelectrical signals in somatic tissues is a powerful modality that might result in profound advances in understanding and augmentation of regenerative capacity.
组织再生需要对生长和形态发生进行精确的协调。一个强大但仍 largely 神秘的生物物理信号系统在再生、胚胎发育和肿瘤形成过程中发挥作用。离子转运体产生 pH 和电压梯度以及离子通量，调节细胞增殖、分化和迁移。内源性生物电信号与伤口愈合、肢体发育、左右模式形成和脊髓再生的控制有关。分子生物学和成像技术的最新进展使人们对离子流动的来源和下游后果有了前所未有的深入了解。作为对当前分子遗传学和干细胞生物学关注重点的补充，对体细胞组织中生物电信号的人工调节是一种强大的方式，可能会在理解和增强再生能力方面取得重大进展。
需注意，“largely”常见释义为“主要地；很大程度上” ，这里根据语境灵活处理为“很大程度上”。
