Bermudez-Silva Francisco Javier, Sanchez-Vera Irene, Suárez Juan, Serrano Antonia, Fuentes Esther, Juan-Pico Pablo, Nadal Angel, Rodríguez de Fonseca Fernando
Fundación IMABIS, Hospital Carlos Haya, Málaga 29010, and Instituto de Bioingeniería, Universidad Miguel Hernández de Elche, Alicante, Spain.
Eur J Pharmacol. 2007 Jun 22;565(1-3):207-11. doi: 10.1016/j.ejphar.2007.02.066. Epub 2007 Apr 20.
Here we show that the activation of cannabinoid CB2 receptors improved glucose tolerance after a glucose load. Blockade of cannabinoid CB2 receptors counteracted this effect, leading to glucose intolerance. Since blockade of cannabinoid CB1 receptors mimics the actions of cannabinoid CB2 receptor agonists, we propose that the endocannabinoid system modulates glucose homeostasis through the coordinated actions of cannabinoid CB1 and CB2 receptors. We also describe the presence of both cannabinoid CB1 and CB2 receptor immunoreactivity in rat pancreatic beta- and non-beta-cells, adding the endocrine pancreas to adipose tissue and the liver as potential sites for endocannabinoid regulation of glucose homeostasis.
我们在此表明，大麻素CB2受体的激活可改善葡萄糖负荷后的糖耐量。大麻素CB2受体的阻断会抵消这种作用，导致葡萄糖不耐受。由于大麻素CB1受体的阻断模拟了大麻素CB2受体激动剂的作用，我们提出内源性大麻素系统通过大麻素CB1和CB2受体的协同作用来调节葡萄糖稳态。我们还描述了大鼠胰腺β细胞和非β细胞中同时存在大麻素CB1和CB2受体免疫反应性，这表明内分泌胰腺与脂肪组织和肝脏一样，是内源性大麻素调节葡萄糖稳态的潜在部位。
