Yambe T, Nitta S, Katahira Y, Sonobe T, Naganuma S, Kakinuma Y, Akiho H, Matsuzawa H, Izutsu K, Kikuchi Y
Department of Medical Engineering and Cardiology, Tohoku University, Sendai, Japan.
Sci Rep Res Inst Tohoku Univ Med. 1991 Jul;38(1):35-41.
To assess the influence of the total artificial heart replacement on autonomic nervous system, sympathetic neurogram was analyzed by power spectrum and coherence function. Two pneumatically driven sac-type ventricular assist devices were implanted as biventricular bypass (BVB) in adult mongrel dogs. After the BVB pumping, natural heart was electrically fibrillated to constitute the BVB type TAH model. Renal sympathetic nerve activity (RSNA) was recorded using the bipolar electrode attached to the left renal sympathetic nerve. RSNA was amplified and integrated by the use of R-C integrator. Power spectra of the RSNA and the values of squared coherence between the arterial pressure waveform and the RSNA were calculated by the computer system. In animal with TAH, coherence at the cardiac rhythm frequency was decreased, and coherence at the TAH pumping rhythm frequency was increased. These results indicate that the arterial pulse wave which was observed in TAH animal contributed to sympathetic neurogram.
为评估全人工心脏置换对自主神经系统的影响，通过功率谱和相干函数分析交感神经图。将两个气动驱动的囊式心室辅助装置作为双心室旁路（BVB）植入成年杂种犬体内。在BVB泵血后，使自然心脏发生电颤动以构建BVB型TAH模型。使用附着于左肾交感神经的双极电极记录肾交感神经活动（RSNA）。RSNA通过R-C积分器进行放大和积分。由计算机系统计算RSNA的功率谱以及动脉压波形与RSNA之间的平方相干值。在接受TAH的动物中，心律频率处的相干性降低，而TAH泵血节律频率处的相干性增加。这些结果表明，在TAH动物中观察到的动脉脉搏波对交感神经图有影响。
