Yambe T, Nitta S, Katahira Y, Sonobe T, Naganuma S, Kakinuma Y, Akiho H, Izutsu K, Kikuchi Y, Tanaka M
Department of Medical Engineering and Cardiology, Tohoku University, Sendai, Japan.
Artif Organs. 1993 Jan;17(1):18-23.
To investigate the drive condition of the artificial heart from a neurophysiological point of view, the dynamic transduction characteristics of the baroreflex system were analyzed by means of sympathetic neurograms. Two pneumatically actuated ventricular assist devices were implanted as biventricular bypasses (BVBs) in adult mongrel dogs to compare the natural heart circulation and prosthetic circulation. After BVB pumping was initiated, the natural heart was electrically fibrillated. Renal sympathetic nerve activity (RSNA) was recorded to analyze sympathetic outflow. Coherence function between the arterial pressure and RSNA was calculated to evaluate the linearity of the baroreflex system. The largest peak coherency was observed when BVB was driven at the frequency of natural heart beat prior to electrical fibrillation, which suggests that the baroreflex system shows the largest linearity at this frequency. These results suggest the possibility that the natural heart beat frequency is the setting frequency at which the baroreflex system transfers the hemodynamic rhythm to the sympathetic outflow.
为了从神经生理学角度研究人工心脏的驱动状况，通过交感神经电图分析了压力感受性反射系统的动态转导特性。将两个气动驱动的心室辅助装置作为双心室旁路（BVB）植入成年杂种犬体内，以比较自然心脏循环和人工循环。在开始BVB泵血后，使自然心脏发生电颤动。记录肾交感神经活动（RSNA）以分析交感神经输出。计算动脉压与RSNA之间的相干函数，以评估压力感受性反射系统的线性度。在电颤动前以自然心跳频率驱动BVB时，观察到最大的峰值相干性，这表明压力感受性反射系统在该频率下表现出最大的线性度。这些结果提示，自然心跳频率可能是压力感受性反射系统将血流动力学节律传递至交感神经输出的设定频率。
