Yambe T, Nitta S, Katahira Y, Sonobe T, Naganuma S, Akiho H, Chiba S, Kakinuma Y, Hayashi H, Izutsu K
Department of Medical Engineering and Cardiology, Tohoku University, Sendai, Japan.
Int J Artif Organs. 1992 Jan;15(1):49-54.
Circulatory maintenance with a left ventricular assist device (LVAD) alone during cardiac arrest until heart transplantation has been evaluated. To assess the effect on the autonomic nervous system, the sympathetic neurogram was analyzed by power spectrum and coherence function. LVAD were inserted between the left atrium and the descending aorta in seven adult mongrel dogs and ventricular fibrillation was induced electrically. Renal sympathetic nerve activity (RSNA) was detected by bipolar electrodes attached to the left renal sympathetic nerve. Values of squared coherence between the arterial pulse wave and RSNA were calculated. Under the condition of circulatory maintenance with only LVAD, coherence at the cardiac rhythm frequency was decreased, and coherence at the LVAD pumping rhythm frequency was increased. These results indicate that the arterial pulse wave observed during maintenance of the circulation with only LVAD contributed to the sympathetic neurogram.
在心脏骤停期间仅使用左心室辅助装置（LVAD）维持循环直至心脏移植已得到评估。为了评估对自主神经系统的影响，通过功率谱和相干函数分析交感神经图。在7只成年杂种犬的左心房和降主动脉之间插入LVAD，并电诱导心室颤动。通过附着在左肾交感神经上的双极电极检测肾交感神经活动（RSNA）。计算动脉脉搏波与RSNA之间的平方相干值。在仅使用LVAD维持循环的情况下，心律频率处的相干性降低，而LVAD泵血节律频率处的相干性增加。这些结果表明，在仅使用LVAD维持循环期间观察到的动脉脉搏波对交感神经图有影响。
