Yambe T
Department of Medical Engineering and Cardiology, Tohoku University, Sendai, Japan.
Sci Rep Res Inst Tohoku Univ Med. 1990 Dec;37(1-4):1-9.
To determine the effect of left ventricular assist device (LVAD) pumping on sympathetic tone, renal sympathetic nerve activity (RSNA) was recorded in acute animal experiments. Our TH-7B pneumatically driven sac type ventricular assist device (VAD) was used in 7 adult mongrel dogs. RSNA was detected by use of bipolar electrodes attached to the left renal sympathetic nerve under conditions of various LVAD pumping modes. All hemodynamic data and the RSNA were calculated with a personal computer system. In general, LVAD assistance produced increased systolic aortic pressure, increased pulmonary artery flow and decreased left atrial pressure, which caused decreased RSNA, especially in the counterpulsation mode. These results suggest that renal vascular resistance might be reduced in parallel with the decrease of RSNA. Thus, counterpulsation mode LVAD assistance has the more evident effect in preventing acute prerenal renal failure.
为了确定左心室辅助装置（LVAD）泵血对交感神经张力的影响，在急性动物实验中记录了肾交感神经活动（RSNA）。我们的TH - 7B气动囊式心室辅助装置（VAD）用于7只成年杂种犬。在各种LVAD泵血模式下，通过连接到左肾交感神经的双极电极检测RSNA。所有血流动力学数据和RSNA均通过个人计算机系统计算得出。一般来说，LVAD辅助可使主动脉收缩压升高、肺动脉血流量增加以及左心房压力降低，这导致RSNA降低，尤其是在反搏模式下。这些结果表明，肾血管阻力可能会随着RSNA的降低而平行降低。因此，反搏模式的LVAD辅助在预防急性肾前性肾衰竭方面具有更明显的效果。
