Nitta S, Yambe T, Katahira Y, Sonobe T, Naganuma S, Kakinuma Y, Tanaka M, Miura M, Sato N, Mohri H
Department of Medical Engineering and Cardiology, Tohoku University, Sendai, Japan.
Sci Rep Res Inst Tohoku Univ Med. 1991 Dec;38(2-4):51-6.
Maintaining circulation with an left ventricular assist device (LVAD) alone during cardiac arrest until heart transplantation, was evaluated by the use of the sympathetic neurogram. To evaluate the influences of this method on autonomic nervous system, sympathetic neurogram was analyzed by power spectrum and coherence function. In acute animal experiments using mongrel dogs, LVAD were implanted. After the LVAD implantation, ventricular fibrillation was induced electrically. Renal sympathetic nerve activity (RSNA) was detected by the use of bipolar electrodes attached to the left renal sympathetic nerve. Values of squared coherence between the arterial pulse wave and RSNA were calculated. Under the condition of circulatory maintenance with LVAD, coherence at the cardiac rhythm frequency was decreased, and coherence at the LVAD pumping rhythm frequency was increased. These results suggest that the arterial pressure which was observed during maintaining the circulation with only LVAD contributed to sympathetic neurogram.
在心脏骤停期间单独使用左心室辅助装置（LVAD）维持循环直至心脏移植，通过交感神经图进行了评估。为了评估该方法对自主神经系统的影响，通过功率谱和相干函数对交感神经图进行了分析。在使用杂种犬的急性动物实验中，植入了LVAD。LVAD植入后，电诱导心室颤动。通过将双极电极连接到左肾交感神经来检测肾交感神经活动（RSNA）。计算动脉脉搏波与RSNA之间的平方相干值。在LVAD维持循环的条件下，心律频率处的相干性降低，而LVAD泵血节律频率处的相干性增加。这些结果表明，仅用LVAD维持循环期间观察到的动脉压对交感神经图有影响。
