Smith P M, Talbot C E, Jeffery N D
Department of Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge, UK.
Vet J. 2008 Jun;176(3):320-5. doi: 10.1016/j.tvjl.2007.03.003. Epub 2007 May 11.
Recurrent seizuring is a common neurological problem in dogs and can present diagnostic difficulties for the attending clinician. Associated interictal neurological deficits strongly suggest brain disease but the frequency of structural abnormalities in patients without such deficits is unknown. In this study the prevalence of clinically significant magnetic resonance imaging (MRI) abnormalities was determined in two groups of interictally normal dogs, those younger than 6 years and those older than 6 years of age. In the former group, only 1/46 dogs (2.2%) had significant MRI abnormalities, whereas in the latter group, 8/30 (26.7%) were abnormal. None of the dogs had an identifiable metabolic cause for the seizures. These findings suggest that the diagnostic yield of advanced neuroimaging techniques in young seizuring dogs without interictal neurological deficits is low, but reaffirms their value in similar older individuals.
反复癫痫发作是犬类常见的神经问题,可能给主治临床医生带来诊断困难。发作间期相关的神经功能缺损强烈提示脑部疾病,但无此类缺损的患者中结构异常的发生率尚不清楚。在本研究中,确定了两组发作间期正常犬类(6岁以下和6岁以上)具有临床意义的磁共振成像(MRI)异常的发生率。在前一组中,只有1/46只犬(2.2%)有明显的MRI异常,而在后一组中,8/30只(26.7%)有异常。没有一只犬的癫痫发作有可识别的代谢原因。这些发现表明,对于无发作间期神经功能缺损的年轻癫痫发作犬,先进神经影像技术的诊断阳性率较低,但再次证实了其在类似老年个体中的价值。