Shlomovitz R, Gov N S
Department of Chemical Physics, The Weizmann Institute of Science, P.O. Box 26, Rehovot, Israel 76100.
Phys Rev Lett. 2007 Apr 20;98(16):168103. doi: 10.1103/PhysRevLett.98.168103.
We present a model which couples the membrane with the protrusive forces of actin polymerization and contractile forces of molecular motors, such as myosin. The actin polymerization at the membrane is activated by freely diffusing membrane proteins that have a spontaneous curvature. Molecular motors are recruited to the polymerizing actin filaments, from a constant reservoir, and produce a contractile force. All the forces and variables are treated in the linear limit. Our results show that for convex membrane proteins the myosin activity gives rise to robust transverse membrane waves, similar to those observed on different cells.
我们提出了一个模型，该模型将细胞膜与肌动蛋白聚合的突出力以及分子马达（如肌球蛋白）的收缩力耦合在一起。细胞膜上的肌动蛋白聚合由具有自发曲率的自由扩散膜蛋白激活。分子马达从恒定的储存库中被招募到正在聚合的肌动蛋白丝上，并产生收缩力。所有的力和变量都在线性极限下进行处理。我们的结果表明，对于凸面膜蛋白，肌球蛋白活性会产生强大的横向膜波，类似于在不同细胞上观察到的膜波。
