Diener Hans-Christoph, Kurth Tobias, Dodick David
Department of Neurology, University Duisburg-Essen, Hufelandstrasse 55, 45122 Essen, Germany.
Curr Pain Headache Rep. 2007 Jun;11(3):236-40. doi: 10.1007/s11916-007-0196-2.
Results from several observational studies indicate an association between migraine and patent foramen ovale (PFO). Several biological mechanisms have been proposed to explain this link, including shared genetic inheritance. However, there is currently insufficient evidence to support a causal link between PFO and migraine. Although the results of uncontrolled observational studies suggest the PFO closure may have a beneficial effect on migraine frequency, a large randomized trial failed to support such a conclusion. Until there is more evidence from ongoing large controlled trials, PFO closure should not be performed in clinical practice for the prophylaxis of migraine.
多项观察性研究结果表明偏头痛与卵圆孔未闭（PFO）之间存在关联。已提出多种生物学机制来解释这种联系，包括共同的遗传遗传。然而，目前尚无足够证据支持PFO与偏头痛之间存在因果关系。尽管非对照观察性研究结果表明PFO封堵术可能对偏头痛发作频率有有益影响，但一项大型随机试验未能支持这一结论。在有正在进行的大型对照试验提供更多证据之前，临床实践中不应进行PFO封堵术来预防偏头痛。
