Malek E, Lebecque P
Service de pédiatrie géenrale, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, Brussels, Belgium.
J Pharm Belg. 2007;62(1):21-4.
In children under 5 years, most lower respiratory tract infections are caused by viruses and do not require antibiotics. This is true for almost all episodes of bronchitis and bronchiolitis but also for the majority of pneumonias. Atypical pneumonias due to Mycoplasma pneumoniae or Chlamydia pneumoniae predominate in older children while Streptococcus pneumoniae remains by far the most common cause of bacterial pneumonia. Diagnosis of pneumonia itself can be difficult and relies on a combination of clinical judgement and radiological and laboratory investigations. In real-life situations, etiologic agents are rarely identified, an issue further complicated by the possibility of mixed infections particularly in hospitalised children. Since viruses are often the sole cause of pneumonia in childhood, it is appropriate not to treat every child with antibiotics. However, when a bacterial origin can not be excluded, antibiotics efficient on Streptococcus pneumoniae are to be prescribed. Amoxicillin is the first choice empirical antibiotic treatment, having a higher efficacy on poorly sensitive pneumococcus than cephalosporins. Macrolides are indicated for the treatment of atypical pneumonia. Current immunisation strategies have decreased the number of bacterial pneumonias. However, there is some evidence that among hospitalised children the rate of complicated pneumonias is increasing with an emerging role of Streptococcus pneumoniae serotype 1, which is not covered in the 7-valent vaccine.
在5岁以下儿童中,大多数下呼吸道感染由病毒引起,无需使用抗生素。几乎所有支气管炎和细支气管炎发作以及大多数肺炎均是如此。肺炎支原体或肺炎衣原体引起的非典型肺炎在大龄儿童中占主导地位,而肺炎链球菌仍然是细菌性肺炎最常见的病因。肺炎本身的诊断可能困难,依赖于临床判断、影像学和实验室检查相结合。在实际情况中,病原体很少能被确定,尤其是在住院儿童中,混合感染的可能性使这一问题更加复杂。由于病毒常常是儿童肺炎的唯一病因,因此对每个儿童都使用抗生素治疗并不恰当。然而,当不能排除细菌感染源时,应开具对肺炎链球菌有效的抗生素。阿莫西林是经验性抗生素治疗的首选,对敏感性差的肺炎球菌的疗效高于头孢菌素。大环内酯类药物用于治疗非典型肺炎。目前的免疫策略已减少了细菌性肺炎的病例数。然而,有证据表明,在住院儿童中,复杂性肺炎的发生率正在上升,肺炎链球菌血清型1起着越来越大的作用,而7价疫苗并未涵盖该血清型。