Hiçsönmez A, Köse K, Andrieu M N, Güney Y, Kurtman C
Department of Radiation Oncology, School of Medicine, Ankara University, Ankara, Turkey.
Eur J Cancer Care (Engl). 2007 May;16(3):251-7. doi: 10.1111/j.1365-2354.2006.00733.x.
The aim of this study was to evaluate the efficacy of palliative radiotherapy in patients with advanced cancer in terms of improvement in the quality of life [quality of life questionnaire (QLQ)], and to assess the correlation between the Eastern Cooperative Oncology Group (ECOG) performance status and the European Organization for Research and Treatment of Cancer (EORTC) QLQ-C30 (Turkish version 3.0). A total of 88 patients with advanced malignant disease treated with palliative radiotherapy were included in the study. All patients completed the EORTC QLQ-C30 questionnaire before and after treatment, and the patient performance status during the pre-treatment and post-treatment phase (ECOG <or= 2, >2) was correlated to the EORTC QLQ C-30 with subscales. Most patients (87.5%) had metastatic disease, and the remaining (12.5%) had locally advanced disease. Comparing the patients in terms of performance status, those with a better performance status (<or=2) reported a statistically significant higher level on the functioning scales and lower levels on all the symptom scales on both the pre-treatment and post-treatment assessments. Cronbach's alphas were calculated to estimate the internal consistency and reliability for both pre- and post-treatment functioning and symptom scales. The results of this study contribute to our understanding of the impact of comprehensive palliative radiotherapy, and to its assessment.
本研究的目的是根据生活质量改善情况[生活质量问卷(QLQ)]评估姑息性放疗对晚期癌症患者的疗效,并评估东部肿瘤协作组(ECOG)体能状态与欧洲癌症研究与治疗组织(EORTC)QLQ-C30(土耳其语版本3.0)之间的相关性。共有88例接受姑息性放疗的晚期恶性疾病患者纳入本研究。所有患者在治疗前和治疗后均完成了EORTC QLQ-C30问卷,治疗前和治疗后阶段的患者体能状态(ECOG≤2,>2)与EORTC QLQ C-30各子量表相关。大多数患者(87.5%)有转移性疾病,其余患者(12.5%)有局部晚期疾病。在体能状态方面比较患者,体能状态较好(≤2)的患者在治疗前和治疗后评估中的功能量表得分在统计学上显著更高,而在所有症状量表上的得分更低。计算Cronbach's α系数以评估治疗前和治疗后功能及症状量表的内部一致性和可靠性。本研究结果有助于我们理解综合姑息性放疗的影响及其评估。