Koo Kaitlin, Zeng Liang, Jon Florencia, Chen Emily, Dennis Kristopher, Holden Lori, Zhang Liying, Caissie Amanda, Nguyen Janet, Tsao May, Barnes Elizabeth, Danjoux Cyril, Sahgal Arjun, Chow Edward
Rapid Response Radiotherapy Program, Department of Radiation Oncology, Odette Cancer Center, Sunnybrook Health Sciences Center, University of Toronto, Toronto, Ontario, Canada.
World J Oncol. 2011 Apr;2(2):70-75. doi: 10.4021/wjon288w. Epub 2011 Apr 9.
The purpose of this study was to investigate quality of life (QOL) in patients receiving palliative radiotherapy (RT) for advanced lung cancer/lung metastases using the EORTC QLQ-LC13 and the EORTC QLQ-C15-PAL questionnaires.
Patients who received palliative RT for lung metastases or advanced lung cancer between November 2007 and October 2010 completed the EORTC QLQ-LC13 and the QLQ-C15-PAL at baseline prior to RT, 1, 2, 4, 8 and 12 weeks post-treatment. The Wilcoxon Signed Rank test was used to compare QOL scores between baseline and each follow-up period.
Thirty-one patients with advanced lung disease were included in this study; 61% of participants were male and 39% were female. The median age was 69 years (range 38 - 85), and median KPS and PPS scores at baseline were both 70 (range 30 - 90). All patients received radiotherapy to the lung. None of the QLQ-LC13 scores significantly improved or deteriorated at any follow-up. Of the QLQ-C15-PAL scales, fatigue, pain, insomnia and physical functioning significantly improved at their respective follow-ups.
This was the first study to use the EORTC QLQ-LC13 in conjunction with the EORTC QLQ-C15-PAL questionnaires. Future studies should continue to incorporate quality of life assessment tools specific to disease characteristics in advanced cancer patients.
本研究旨在使用欧洲癌症研究与治疗组织（EORTC）QLQ-LC13和EORTC QLQ-C15-PAL问卷，调查接受姑息性放疗（RT）的晚期肺癌/肺转移患者的生活质量（QOL）。
2007年11月至2010年10月期间接受肺转移或晚期肺癌姑息性放疗的患者，在放疗前基线、治疗后1、2、4、8和12周完成EORTC QLQ-LC13和QLQ-C15-PAL问卷。采用Wilcoxon符号秩检验比较基线和各随访期的生活质量评分。
本研究纳入了31例晚期肺病患者；61%的参与者为男性，39%为女性。中位年龄为69岁（范围38 - 85岁），基线时中位KPS和PPS评分均为70（范围30 - 90）。所有患者均接受了肺部放疗。在任何随访中，QLQ-LC13评分均无显著改善或恶化。在QLQ-C15-PAL量表中，疲劳、疼痛、失眠和身体功能在各自的随访中均有显著改善。
这是第一项将EORTC QLQ-LC13与EORTC QLQ-C15-PAL问卷结合使用的研究。未来的研究应继续纳入针对晚期癌症患者疾病特征的生活质量评估工具。
