Kafrouni Michel I, Anders Robert A, Verma Sumita
Division of Gastroenterology and Hepatology, Department of Medicine, Johns Hopkins University Hospital, Baltimore, Maryland, USA.
Clin Gastroenterol Hepatol. 2007 Jul;5(7):809-12. doi: 10.1016/j.cgh.2007.02.036. Epub 2007 May 16.
BACKGROUND & AIMS: The aim of this article was to re-emphasize the hepatotoxicity associated with the use of anabolic androgenic steroids and to highlight the marketing and sale of anabolic androgenic steroids as dietary supplements.
This was a case series of 2 patients who developed a cholestatic liver panel after consumption of anabolic androgenic steroids. A detailed Pubmed/Medline search was performed to research this topic.
We present 2 young men who developed significant cholestatic liver injury after consumption of anabolic androgenic steroids. This was associated with considerable morbidity, although both patients recovered without the need for a liver transplant. Both of these anabolic androgenic steroids were being marketed as dietary supplements.
Despite being classified as class III controlled substances, anabolic androgenic steroids are still a cause for serious hepatotoxicity in the United States. Some of these anabolic androgenic steroids are being marketed as dietary supplements. Although the Food and Drug Administration is making concerted efforts to regulate this, increased vigilance also is required from the medical profession.
本文旨在再次强调与使用合成代谢雄激素类固醇相关的肝毒性，并突出合成代谢雄激素类固醇作为膳食补充剂的营销与销售情况。
这是一个包含2例患者的病例系列，这2例患者在服用合成代谢雄激素类固醇后出现胆汁淤积性肝功能指标异常。我们对该主题进行了详细的PubMed/Medline检索。
我们呈现了2名年轻男性，他们在服用合成代谢雄激素类固醇后出现了严重的胆汁淤积性肝损伤。这与相当高的发病率相关，不过两名患者均康复，无需进行肝移植。这两种合成代谢雄激素类固醇均作为膳食补充剂进行销售。
尽管合成代谢雄激素类固醇被归类为III类管制物质，但在美国仍是严重肝毒性的一个病因。其中一些合成代谢雄激素类固醇正作为膳食补充剂进行销售。尽管美国食品药品监督管理局正在齐心协力进行监管，但医疗行业也需要提高警惕。
