Stępień Piotr M, Reczko Katarzyna, Wieczorek Anna, Zarębska-Michaluk Dorota, Pabjan Paweł, Król Teodora, Kryczka Wiesław
Clinic of Infectious Diseases, Regional Polyclinic Hospital, Kielce, Poland.
Department of Cell Biology and Electron Microscopy, Institute of Biology, Jan Kochanowski University, Kielce, Poland.
Clin Exp Hepatol. 2015 May;1(1):30-33. doi: 10.5114/ceh.2015.51376. Epub 2015 Apr 30.
Stanozolol is a 17α-alkylated synthetic anabolic steroid used illegally by bodybuilders. We present a 19-year-old man who was taking 50 mg of stanozolol intramuscularly, every other day for 2 months, to improve muscle mass. On admission, his bilirubin concentration was 44.34 mg/dl. The serum levels of liver enzymes were normal, with only alanine aminotransferase being slightly elevated. Liver biopsy revealed toxic hepatitis of minor grade with periportal fibrosis and intrahepatic cholestasis. Medical treatment of the patient was conservative. Despite the therapy the patient's general condition deteriorated - bilirubin level increased to 56.64 mg/dl, and INR rose to 1.7. Then we decided to administer low doses of hydrocortisone. As a result of the treatment, bilirubin concentration was 14.61 mg/dl after 2 weeks. Finally all hepatic enzymes returned to normal values 5 months after stanozolol was discontinued. This treatment appears to be safe and leads to a more rapid reduction of bilirubin.
司坦唑醇是一种17α-烷基化合成代谢类固醇，被健美运动员非法使用。我们报告一名19岁男性，他每隔一天肌肉注射50毫克司坦唑醇，持续2个月以增加肌肉量。入院时，他的胆红素浓度为44.34毫克/分升。血清肝酶水平正常，仅丙氨酸转氨酶略有升高。肝活检显示轻度中毒性肝炎伴门周纤维化和肝内胆汁淤积。对该患者的治疗采取保守治疗。尽管进行了治疗，患者的一般状况仍恶化——胆红素水平升至56.64毫克/分升，国际标准化比值（INR）升至1.7。然后我们决定给予低剂量氢化可的松。治疗2周后，胆红素浓度降至14.61毫克/分升。最终，在停用司坦唑醇5个月后，所有肝酶均恢复至正常水平。这种治疗似乎是安全的，能使胆红素更快降低。
