来自海南链珠藤的细胞毒性强心苷。

Cytotoxic cardenolides from Streptocaulon griffithii.

作者信息

Zhang Xiao-Hui, Zhu Hui-Lin, Yu Qiang, Xuan Li-Jiang

机构信息

State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institute for Biological Sciences, Chinese Academy of Science, 555 Zuchongzhi Road, Zhangjiang Hi-Tech Park, Shanghai 201203, PR China.

出版信息

Chem Biodivers. 2007 May;4(5):998-1002. doi: 10.1002/cbdv.200790091.

DOI:10.1002/cbdv.200790091

PMID:17510995

Abstract

A new cardenolide, 3-O-(beta-glucopyranosyl)acovenosigenin A (1), was isolated from the roots of Streptocaulon griffithii, together with eight known cardenolides, compounds 2-9. All compounds showed significant in vitro inhibition of the proliferation of the human gastrointestinal cancer cell line HGC-27, with IC50 values in the range of ca. 20-564 nM, taxol being used as positive control. Compound 1 was also found to be strongly cytotoxic against other human tumor cell lines, including A549, MCF-7, and Hela cells.

摘要

从披针叶链珠藤的根中分离出一种新的强心苷，3 - O -（β - 吡喃葡萄糖基）阿考韦苷元A（1），以及8种已知的强心苷，化合物2 - 9。所有化合物在体外均对人胃肠道癌细胞系HGC - 27的增殖表现出显著抑制作用，IC50值约为20 - 564 nM，以紫杉醇作为阳性对照。还发现化合物1对包括A549、MCF - 7和Hela细胞在内的其他人类肿瘤细胞系具有很强的细胞毒性。