Jakola A S, Müller K, Larsen M, Waterloo K, Romner B, Ingebrigtsen T
Faculty of Medicine, University of Tromsø, Tromsø, Norway.
Acta Neurol Scand. 2007 Jun;115(6):398-402. doi: 10.1111/j.1600-0404.2007.00827.x.
To study the prevalence of post-concussion symptoms (PCS) 5-7 years after mild head injury (MHI) and to investigate whether patients suffer from more symptoms than the normal population.
We conducted a 5- to 7-year follow-up of patients (n = 89) with MHI. Post-concussion symptoms were quantified with the Rivermead Post Concussion Symptoms Questionnaire (RPQ) and health-related quality of life (HRQL) was measured with the EuroQol-5D (EQ-5D). We also quantified subjective general health state with the EuroQol Visual Analogue Scale (EQ-VAS). An age- and sex-matched, but otherwise randomly chosen control group of 89 persons was recruited from the National Population Registry for a cross-sectional comparison. Twenty-eight patients (30%) and 27 (30%) controls responded.
Patients reported significantly (P = 0.017) more PCS (median RPQ score 10, 95% CI 2-20) than controls (median 2, 95% CI 0-4). They also reported significantly (P = 0.008) lower HRQL (median EQ-5D score 0.866, 95% CI 0.796-1.000) than controls (1.000, 95% CI 1.000-1.000), but there was no difference between the groups in their subjective ratings of general health state.
Patients reported significantly more PCS and lower HRQL 5 to 7 years after MHI than age- and sex-matched controls from the normal population.
研究轻度头部损伤(MHI)后5至7年的脑震荡后症状(PCS)患病率,并调查患者是否比正常人群出现更多症状。
我们对89例MHI患者进行了5至7年的随访。使用Rivermead脑震荡后症状问卷(RPQ)对脑震荡后症状进行量化,并用欧洲五维健康量表(EQ-5D)测量健康相关生活质量(HRQL)。我们还使用欧洲五维视觉模拟量表(EQ-VAS)对主观总体健康状况进行量化。从国家人口登记处招募了一个由89人组成的年龄和性别匹配但其他方面随机选择的对照组,进行横断面比较。28例患者(30%)和27例(30%)对照者做出了回应。
患者报告的PCS显著多于对照组(P = 0.017)(RPQ中位数评分10,95%可信区间2 - 20),而对照组为(中位数2,95%可信区间0 - 4)。他们报告的HRQL也显著低于对照组(P = 0.008)(EQ-5D中位数评分0.866,95%可信区间0.796 - 1.000),而对照组为(1.000,95%可信区间1.000 - 1.000),但两组在总体健康状况的主观评分上没有差异。
与正常人群中年龄和性别匹配的对照组相比,MHI后5至7年的患者报告的PCS显著更多,HRQL更低。