Bullitt Elizabeth, Reardon David A, Smith J Keith
CASILab, CB # 7062, University of North Carolina, Chapel Hill, NC 27599, USA.
Neuroimage. 2007;37 Suppl 1(Suppl 1):S116-9. doi: 10.1016/j.neuroimage.2007.03.067. Epub 2007 Apr 25.
There is currently no noninvasive, reliable method of assessing brain tumor malignancy or of monitoring tumor treatment response. Monitoring changes to tumor vasculature might provide an effective means of assessing both tumor aggressiveness and treatment efficacy. To date, most such research has concentrated upon tumor "microvascular" imaging, with permeability and/or perfusion imaging used to assess vessel changes at the subvoxel level. An alternative approach assesses tumor vasculature at the "macroscopic" level, calculating the numbers and shapes of the larger vessels discriminable by magnetic resonance angiography. This paper provides an overview of magnetic resonance (MR) vascular imaging at both the microscopic (dynamic MR perfusion and permeability) and macroscopic (MR angiographic) levels. The two approaches provide different, complementary information and together could provide important insights into cancer growth as well as new methods of assessing malignancy and tumor treatment response.
目前尚无评估脑肿瘤恶性程度或监测肿瘤治疗反应的无创、可靠方法。监测肿瘤血管系统的变化可能提供一种评估肿瘤侵袭性和治疗效果的有效手段。迄今为止，大多数此类研究都集中在肿瘤“微血管”成像上，利用通透性和/或灌注成像来评估亚体素水平的血管变化。另一种方法是在“宏观”层面评估肿瘤血管系统，计算磁共振血管造影可分辨的较大血管的数量和形状。本文概述了微观层面（动态磁共振灌注和通透性）和宏观层面（磁共振血管造影）的磁共振（MR）血管成像。这两种方法提供了不同的互补信息，共同可为癌症生长提供重要见解，以及评估恶性程度和肿瘤治疗反应的新方法。
