Nishio Yoshiyuki, Ishii Kazunari, Kazui Hiroaki, Hosokai Yoshiyuki, Mori Etsuro
Department of Behavioral Neurology and Cognitive Neuroscience, Tohoku University Graduate School of Medicine, Sendai, Japan.
J Neurol Sci. 2007 Sep 15;260(1-2):271-4. doi: 10.1016/j.jns.2007.04.021. Epub 2007 May 21.
A patient developed frontal-lobe syndrome and psychotic symptoms after infarction in the pontomesencephalic junction. Stereotaxic lesion localization on magnetic resonance imaging and statistical analyses of regional cerebral blood flow (rCBF) disclosed an involvement of the rostral brainstem dopaminergic nuclei and hypoperfusion in the frontal-subcortical circuit components. We suggest that the patient's cognitive and behavioral disturbances were associated with disruption of ascending dopaminergic projections to the frontal-subcortical circuits.
一名患者在脑桥中脑交界处梗死之后出现了额叶综合征和精神症状。磁共振成像上的立体定向病变定位以及局部脑血流（rCBF）的统计分析显示，患者的喙侧脑干多巴胺能核受累，额叶-皮质下环路成分存在灌注不足。我们认为，该患者的认知和行为障碍与额叶-皮质下环路的多巴胺能上行投射中断有关。
