Noda Koji, Furukawa Takuji, Fujisawa Takashi, Iwata Yoshiyuki, Kanai Tatsuaki, Kanazawa Mitsutaka, Kitagawa Atsushi, Komori Masataka, Minohara Shinichi, Murakami Takeshi, Muramatsu Masayuki, Sato Shinji, Takei Yuka, Tashiro Mutsumi, Torikoshi Masami, Yamada Satoru, Yusa Ken
Department of Accelerator and Medical Physics, National Institute of Radiological Sciences.
J Radiat Res. 2007;48 Suppl A:A43-54. doi: 10.1269/jrr.48.a43.
The first clinical trial with carbon beams generated from HIMAC was conducted in June 1994. The total number of patients treated as of December 2006 was in excess of 3,000. In view of the significant growth in the number of protocols, the Japanese government gave its approval for carbon-ion therapy at NIRS as an advanced medical technology in 2003. The impressive advances of carbon-ion therapy using HIMAC have been supported by high-reliability operation and by advanced developments of beam-delivery and accelerator technologies. Based on our ten years of experience with HIMAC, we recently proposed a new accelerator facility for cancer therapy with carbon ions for widespread use in Japan. The key technologies of the accelerator and beam-delivery systems for this proposed facility have been under development since April 2004, with the main thrust being focused on downsizing the facility for cost reduction. Based on the design and R&D studies for the proposed facility, its construction was begun at Gunma University in April 2006. In addition, our future plans for HIMAC also include the design of a new treatment facility. The design work has already been initiated, and will lead to the further development of therapy using HIMAC. The following descriptions give a summary account of the new accelerator facility for cancer therapy with carbon ions and of the new treatment facility at HIMAC.
1994年6月开展了首次使用HIMAC产生的碳离子束进行的临床试验。截至2006年12月，接受治疗的患者总数超过3000人。鉴于治疗方案数量显著增加，日本政府于2003年批准国立放射医学综合研究所的碳离子治疗为先进医疗技术。使用HIMAC的碳离子治疗取得的显著进展得益于高可靠性运行以及束流传输和加速器技术的先进发展。基于我们在HIMAC方面的十年经验，我们最近提出了一种用于癌症碳离子治疗的新型加速器设施，以便在日本广泛应用。自2004年4月以来，一直在开发该拟建设施的加速器和束流传输系统的关键技术，主要重点是缩小设施规模以降低成本。基于对拟建设施的设计和研发研究，于2006年4月在群马大学开始建设。此外，我们对HIMAC的未来规划还包括设计一个新的治疗设施。设计工作已经启动，这将推动使用HIMAC的治疗进一步发展。以下介绍对用于癌症碳离子治疗的新型加速器设施以及HIMAC的新治疗设施进行了简要说明。
