Campisi Judith
Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.
Aging Cell. 2007 Jun;6(3):261-3. doi: 10.1111/j.1474-9726.2007.00292.x.
This Hot Topics review, the second in a new Aging Cell series, discusses articles published in the last year that have stimulated new ideas about the tangled relationship of aging to cancer cell biology. The year's highlights include reports on the ability of Mdm2 mutations to diminish risks of cancer in aging mice, on proliferative competition between oncogenic cells and bone marrow stem cells, and on the role of metalloproteinases in overcoming age-associated barriers to tumor invasion. Of particular interest were three articles showing that diminished activity of the tumor-suppressor gene p16/INK4a, while increasing the risk of cancer mortality, can lead to improved function in several varieties of age-sensitive stem cells.
本热点综述是《衰老细胞》新系列中的第二篇，讨论了去年发表的一些文章，这些文章激发了关于衰老与癌细胞生物学复杂关系的新观点。本年度的亮点包括：关于Mdm2突变降低衰老小鼠患癌风险的报道、致癌细胞与骨髓干细胞之间的增殖竞争，以及金属蛋白酶在克服与年龄相关的肿瘤侵袭障碍中的作用。特别值得关注的是三篇文章，它们表明肿瘤抑制基因p16/INK4a活性降低，虽然会增加癌症死亡风险，但能改善多种年龄敏感干细胞的功能。
