Taschieri Silvio, Del Fabbro Massimo, Testori Tiziano, Weinstein Roberto
Department of Odontology, Istituto Ortopedico Galeazzi I.R.C.C.S., University of Milan, Milan, Italy.
J Oral Maxillofac Surg. 2007 Jun;65(6):1121-7. doi: 10.1016/j.joms.2006.10.022.
The purpose of this prospective clinical trial was to monitor the outcomes of periradicular surgery in large periapical lesions with or without guided tissue regeneration (GTR) and anorganic bovine bone.
All teeth in the study revealed a periradicular lesion measuring at least 10 mm. A total of 63 teeth in 44 patients were included according to specific selection criteria. In the test group, after root end filling was completed, the defect was filled with anorganic bovine bone and was covered with a resorbable collagen membrane. In the control group, neither graft nor membrane was used.
A total of 59 teeth in 41 patients were evaluable at 1-year follow-up. Of these, 24 teeth belonged to the test group and 35 to the control group. Overall, 46 teeth (78%) had successfully healed, 10 (16.9%) demonstrated uncertain healing, and 3 exhibited treatment failure. Investigators found no statistically significant differences in outcome between test and control groups.
The present study showed that the use of GTR in association with anorganic bovine bone in the treatment of patients with large periradicular lesions of strictly endodontic origin has no beneficial effect on outcome.
本前瞻性临床试验的目的是监测在有或没有引导组织再生（GTR）及无机牛骨的情况下，根尖周大病变进行根尖周手术的结果。
研究中的所有牙齿均显示根尖周病变至少10毫米。根据特定选择标准，纳入了44例患者的63颗牙齿。在试验组中，完成根充后，用无机牛骨填充缺损并用可吸收胶原膜覆盖。在对照组中，既未使用移植材料也未使用膜。
41例患者的59颗牙齿在1年随访时可进行评估。其中，24颗牙齿属于试验组，35颗属于对照组。总体而言，46颗牙齿（78%）成功愈合，10颗（16.9%）愈合情况不确定，3颗出现治疗失败。研究者发现试验组和对照组在结果上无统计学显著差异。
本研究表明，在治疗严格牙髓源性根尖周大病变患者时，联合使用GTR和无机牛骨对结果没有有益影响。
