Niu Xue-Mei, Li Sheng-Hong, Görls Helmar, Schollmeyer Dieter, Hilliger Matthias, Grabley Susanne, Sattler Isabel
Leibniz-Institute for Natural Product Research and Infection Biology, Hans-Knöll-Institute, Beutenbergstrasse 11a, D-07745 Jena, Germany.
Org Lett. 2007 Jun 21;9(13):2437-40. doi: 10.1021/ol0705999. Epub 2007 May 24.
Abyssomicin E (1), a new polycyclic metabolite with a C19 skeleton, was isolated from Streptomyces sp. (HKI0381). Its chemical structure was determined by comprehensive NMR and MS spectroscopic analyses. For the first time in this recently discovered class of compounds, the absolute stereochemistry was directly established by subsequent single-crystal X-ray diffraction study using anomalous dispersion with copper radiation.
深渊霉素E（1）是一种具有C19骨架的新型多环代谢产物，从链霉菌属（HKI0381）中分离得到。其化学结构通过综合核磁共振和质谱光谱分析确定。在这类最近发现的化合物中，首次通过随后使用铜辐射的反常色散进行的单晶X射线衍射研究直接确定了绝对立体化学。
