Wang Xiachang, Elshahawi Sherif I, Cai Wenlong, Zhang Yinan, Ponomareva Larissa V, Chen Xiabin, Copley Gregory C, Hower James C, Zhan Chang-Guo, Parkin Sean, Rohr Jürgen, Van Lanen Steven G, Shaaban Khaled A, Thorson Jon S
Center for Applied Energy Research, University of Kentucky , Lexington, Kentucky 40511, United States.
Department of Chemistry, University of Kentucky , Lexington, Kentucky 40506, United States.
J Nat Prod. 2017 Apr 28;80(4):1141-1149. doi: 10.1021/acs.jnatprod.7b00108. Epub 2017 Mar 30.
The structures of 12 new "enantiomeric"-like abyssomicin metabolites (abyssomicins M-X) from Streptomyces sp. LC-6-2 are reported. Of this set, the abyssomicin W (11) contains an unprecedented 8/6/6/6 tetracyclic core, while the bicyclic abyssomicin X (12) represents the first reported naturally occurring linear spirotetronate. Metabolite structures were determined based on spectroscopic data and X-ray crystallography, and Streptomyces sp. LC-6-2 genome sequencing also revealed the corresponding putative biosynthetic gene cluster.
报道了链霉菌属LC-6-2产生的12种新的类对映体阿比斯霉素代谢产物（阿比斯霉素M-X）的结构。在这一组中，阿比斯霉素W（11）含有前所未有的8/6/6/6四环核心，而双环阿比斯霉素X（12）是首次报道的天然存在的线性螺四环内酯。代谢产物结构通过光谱数据和X射线晶体学确定，链霉菌属LC-6-2的基因组测序也揭示了相应的假定生物合成基因簇。
