视网膜神经节细胞感受野的峰间间隔分析
Interspike interval analysis of retinal ganglion cell receptive fields.
作者信息
Rathbun Daniel L, Alitto Henry J, Weyand Theodore G, Usrey W Martin
机构信息
Center for Neuroscience, University of California, Davis, California 95618, USA.
出版信息
J Neurophysiol. 2007 Aug;98(2):911-9. doi: 10.1152/jn.00802.2006. Epub 2007 May 23.
Abstract
The interspike interval (ISI) preceding a retinal spike has a strong influence on whether retinal spikes will drive postsynaptic responses in the lateral geniculate nucleus (LGN). This ISI-based filtering of retinal spikes could, in principle, be used as a mechanism for processing visual information en route from retina to cortex; however, this form of processing has not been previously explored. Using a white noise stimulus and reverse correlation analysis, we compared the receptive fields associated with retinal spikes over a range of ISIs (0-120 ms). Results showed that, although the location and sign of retinal ganglion cell receptive fields are invariant to ISI, the size and amplitude of receptive fields vary with ISI. These results support the notion that ISI-based filtering of retinal spikes can serve as a mechanism for shaping receptive fields.
摘要
视网膜尖峰之前的峰间间隔（ISI）对视网膜尖峰是否会驱动外侧膝状体（LGN）中的突触后反应有很大影响。原则上，这种基于ISI对视网膜尖峰的筛选可作为一种在从视网膜到皮层的信息传递过程中处理视觉信息的机制；然而，此前尚未对这种处理形式进行过探索。我们使用白噪声刺激和反向相关分析，比较了一系列ISI（0 - 120毫秒）范围内与视网膜尖峰相关的感受野。结果表明，尽管视网膜神经节细胞感受野的位置和符号对ISI不变，但感受野的大小和幅度会随ISI而变化。这些结果支持了基于ISI对视网膜尖峰进行筛选可作为塑造感受野机制的观点。
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