Lippert-Grüner Marcela, Maegele Marc, Haverkamp Heinz, Klug Norfrid, Wedekind Christoph
Department of Neurosurgery, University of Cologne, Cologne, Germany.
Brain Inj. 2007 May;21(5):451-5. doi: 10.1080/02699050701343961.
The increasing number of patients surviving severe traumatic brain injury (sTBI) but with significant sensorimotor and neuropsychological deficits is a challenge to rehabilitation medicine. So far, most research initiatives have focused on mortality rates, physiological or economic parameters to estimate therapeutic effects of rehabilitation strategies. Investigations on health-related quality of life (HRQoL) after TBI with and without concomitant polytrauma are rare compared to other disorders.
DESIGN/PATIENTS: A prospective study was conducted to investigate HRQoL using the SF-36 questionnaire in 49 patients with sTBI (Glasgow Coma Scale < 9 for more than 24 hours) with and without concomitant polytrauma 6 and 12 months after injury.
The SF-36 score profiles 6 and 12 months after trauma were similar. Scores 12 months after trauma, however, were higher in 7/8 dimensions indicating an improvement over time. Similar observations were made for physical and mental sum scores. There was no difference in the SF-36 scoring pattern between the patients with isolated TBI and the patients with concomitant polytrauma, except for physical functioning after 12 months.
While there is significant overall improvement of HRQoL over time, sTBI appears to bear major influence on post-traumatic HRQoL and outcome.
重型颅脑损伤（sTBI）幸存者数量不断增加，但伴有明显的感觉运动和神经心理缺陷，这对康复医学构成了挑战。到目前为止，大多数研究项目都集中在死亡率、生理或经济参数上，以评估康复策略的治疗效果。与其他疾病相比，关于伴有或不伴有多发伤的TBI后健康相关生活质量（HRQoL）的研究很少。
设计/患者：进行了一项前瞻性研究，使用SF-36问卷对49例sTBI患者（格拉斯哥昏迷量表<9超过24小时）在受伤后6个月和12个月时伴有或不伴有多发伤的HRQoL进行调查。
创伤后6个月和12个月时的SF-36评分概况相似。然而，创伤后12个月时，8个维度中有7个维度的评分更高，表明随着时间的推移有所改善。身体和心理总分也有类似的观察结果。除了12个月后的身体功能外，单纯TBI患者和伴有多发伤患者的SF-36评分模式没有差异。
虽然随着时间的推移HRQoL有显著的总体改善，但sTBI似乎对创伤后的HRQoL和结果有重大影响。
