[角叉菜胶对小鼠抵抗脂多糖诱导的内毒素血症非特异性抵抗力的影响]

[Effect of carrageenan on non-specific resistance to LPS-induced endotoxemia in mice].

作者信息

Khasina E I, Sgrebneva M N, Ermak I M, Maleev V V

出版信息

Zh Mikrobiol Epidemiol Immunobiol. 2007 Mar-Apr(2):57-60.

Abstract

The study showed that kappa/lamda-carrageenan increase non-specific resistance to impact of Escherichia coli lypopolysaccharide (LPS)-induced endotoxinemia in mice. Carrageenan was administered intragastrically in dose 100 mg/kg/day during 5 days followed by intraperitoneal injection of LPS in dose 1 mg/kg. Carrageenan hampered the involution of thymus, hypertrophy of adrenal glands, the changes on level of thyroid hormones and corticosterone in serum, the activation of glycogenolysis, glycolysis, and peroxidation of lipids in liver.

摘要

研究表明，κ/λ-卡拉胶可增强小鼠对大肠杆菌脂多糖（LPS）诱导的内毒素血症影响的非特异性抵抗力。在5天内以100mg/kg/天的剂量胃内给予卡拉胶，随后腹腔注射1mg/kg的LPS。卡拉胶抑制了胸腺退化、肾上腺肥大、血清中甲状腺激素和皮质酮水平的变化、肝糖原分解、糖酵解以及脂质过氧化的激活。