Rader Aaron W, France Christopher R, Carlson Bruce
American Red Cross Blood Services, Central Ohio Region, Ohio, USA.
Transfusion. 2007 Jun;47(6):995-1001. doi: 10.1111/j.1537-2995.2007.01223.x.
Although reactions to whole-blood (WB) donation are known to decrease donor retention, potential effects of reactions to automated double red cell (2RBC) donation upon retention have not been investigated.
The authors investigated effects of donor status (first-time, experienced) and reactions (absent, present) upon retention of all male allogeneic WB and 2RBC donors (n = 45,296) donating within the American Red Cross Central Ohio Region during a 12-month period. Donor age, race, and status (first-time, experienced); phlebotomist's reaction rating; and phlebotomy procedure (WB, 2RBC) were collected for the initial donation by each donor. Dates of any donation attempts in the 12 months starting from the donor's first eligible date after the initial donation were also collected.
On average, WB donors were less likely to react and more likely to donate again and returned more quickly to donate than 2RBC donors, even after accounting for differential delays in eligibility. Reactions decreased the likelihood of repeat donation among all first-time donors regardless of initial phlebotomy procedure. Among experienced donors, however, reactions depressed retention of WB donors by 27.6 percent, whereas reactions lowered retention of 2RBC donors by just 3.6 percent.
Although 2RBC donors were more likely to react, first-time 2RBC donors were no more affected by reactions than first-time WB donors. Experienced WB donors suffered a larger drop in retention as a function of reactions, in fact, than did experienced donors who gave 2RBC donations. Potential reasons for this data pattern require further investigation.
虽然已知全血（WB）捐献反应会降低献血者保留率，但自动双红细胞（2RBC）捐献反应对保留率的潜在影响尚未得到研究。
作者调查了献血者状态（首次、有经验）和反应（无、有）对美国红十字会俄亥俄州中部地区12个月内所有男性异体全血和双红细胞献血者（n = 45,296）保留率的影响。收集了每位献血者首次献血时的年龄、种族和状态（首次、有经验）；采血人员的反应评分；以及采血程序（全血、双红细胞）。还收集了从首次献血后的首次合格日期开始的12个月内任何献血尝试的日期。
平均而言，即使考虑到资格差异延迟，全血献血者发生反应的可能性较小，再次献血的可能性较大，且比双红细胞献血者更快恢复献血。反应降低了所有首次献血者再次献血的可能性，无论最初的采血程序如何。然而，在有经验的献血者中，反应使全血献血者的保留率降低了27.6%，而反应仅使双红细胞献血者的保留率降低了3.6%。
虽然双红细胞献血者更有可能发生反应，但首次双红细胞献血者受反应的影响并不比首次全血献血者更大。事实上，有经验的全血献血者因反应导致的保留率下降幅度比有经验的双红细胞献血者更大。这种数据模式的潜在原因需要进一步调查。
