Range N, Magnussen P, Mugomela A, Malenganisho W, Changalucha J, Temu M M, Mngara J, Krarup H, Friis H, Andersen A B
National Institute for Medical Research, Muhimbili Medical Research Station, PO Box 3436, Dar es Salaam, Tanzania.
Ann Trop Med Parasitol. 2007 Jun;101(4):343-51. doi: 10.1179/136485907X176373.
A cross-sectional study was conducted in Mwanza, Tanzania, to determine the burden of HIV and parasitic co-infections among patients who were confirmed or suspected cases of pulmonary tuberculosis (PTB). Of the 655 patients investigated, 532 (81.2%) had been confirmed as PTB cases, by microscopy and/or culture (PTB+), whereas the other 123 (18.8%) were only suspected cases, on the basis of other clinical criteria (PTB-). Hookworm and Schistosoma mansoni infections were common in the patients, with prevalences of 18% and 34%, respectively. Malarial, Ascaris lumbricoides, Trichuris trichiura and Strongyloides stercoralis infections were less common, each recorded at a prevalence of <5%. The PTB+ patients were less likely to be HIV-positive than the PTB- patients (43.6% v. 62.6%; P<0.0001). Among the PTB+ patients, the HIV-positive had a significantly lower prevalence (12.1% v. 25%; P<0.0001) and mean intensity (49 v. 123 eggs/g; P=0.003) of hookworm infection than the HIV-negative. The PTB patients in the study area were, however, still frequently co-infected with HIV and with parasitic infections that may increase morbidity and accelerate the progression of HIV disease.
在坦桑尼亚的姆万扎进行了一项横断面研究，以确定确诊或疑似肺结核（PTB）患者中艾滋病毒和寄生虫合并感染的负担。在655名接受调查的患者中，532名（81.2%）通过显微镜检查和/或培养被确诊为PTB病例（PTB+），而另外123名（18.8%）仅根据其他临床标准被怀疑为病例（PTB-）。钩虫和曼氏血吸虫感染在患者中很常见，患病率分别为18%和34%。疟疾、蛔虫、鞭虫和粪类圆线虫感染较少见，每种感染的患病率均<5%。PTB+患者比PTB-患者感染艾滋病毒的可能性更小（43.6%对62.6%；P<0.0001）。在PTB+患者中，艾滋病毒阳性者钩虫感染的患病率（12.1%对25%；P<0.0001）和平均强度（49对123个虫卵/克；P=0.003）显著低于艾滋病毒阴性者。然而，研究区域内的PTB患者仍经常合并感染艾滋病毒和寄生虫感染，这可能会增加发病率并加速艾滋病毒疾病的进展。
