创伤后应激障碍患者在恐惧非意识加工过程中杏仁核及内侧前额叶激活增强：一项功能磁共振成像研究
Enhanced amygdala and medial prefrontal activation during nonconscious processing of fear in posttraumatic stress disorder: an fMRI study.
作者信息
Bryant Richard A, Kemp Andrew H, Felmingham Kim L, Liddell Belinda, Olivieri Gloria, Peduto Anthony, Gordon Evian, Williams Leanne M
机构信息
Brain Dynamics Centre, Westmead Hospital, Sydeny, New South Wales, Australia.
出版信息
Hum Brain Mapp. 2008 May;29(5):517-23. doi: 10.1002/hbm.20415.
Abstract
Biological models of posttraumatic stress disorder (PTSD) suggest that patients will display heightened amygdala but decreased medial prefrontal activity during processing of fear stimuli. However, a rapid and automatic alerting mechanism for responding to nonconscious signals of fear suggests that PTSD may display heightened rather than decreased MPFC under nonconscious processing of fear stimuli. This study used functional magnetic resonance imaging to examine blood oxygenation level-dependent signal changes during nonconscious presentation (16.7 ms, masked) of fearful and neutral faces in 15 participants with PTSD and 15 age and sex-matched healthy control participants. Results indicate that PTSD participants display increased amygdala and MPFC activity during nonconscious processing of fearful faces. These data extend existing models by suggesting that the impaired MPFC activation in PTSD may be limited to conscious fear processing. Hum Brain Mapp, 2008. (c) 2007 Wiley-Liss, Inc.
摘要
创伤后应激障碍（PTSD）的生物学模型表明，患者在处理恐惧刺激时杏仁核活动增强，但内侧前额叶活动减弱。然而，一种用于对无意识恐惧信号做出反应的快速自动警报机制表明，在对恐惧刺激进行无意识处理时，PTSD患者的内侧前额叶皮质（MPFC）可能会增强而非减弱。本研究使用功能磁共振成像来检查15名PTSD患者以及15名年龄和性别匹配的健康对照参与者在无意识呈现（16.7毫秒，掩蔽）恐惧和中性面孔期间的血氧水平依赖信号变化。结果表明，PTSD参与者在无意识处理恐惧面孔时杏仁核和MPFC活动增加。这些数据扩展了现有模型，表明PTSD中MPFC激活受损可能仅限于有意识的恐惧处理。《人类大脑图谱》，2008年。（c）2007威利 - 利斯公司。
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